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Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk
The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndrome in the (Prevenc...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521014/ https://www.ncbi.nlm.nih.gov/pubmed/30939748 http://dx.doi.org/10.3390/nu11040761 |
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author | Papandreou, Christopher Babio, Nancy Díaz-López, Andrés Martínez-González, Miguel Á. Becerra-Tomas, Nerea Corella, Dolores Schröder, Helmut Romaguera, Dora Vioque, Jesús Alonso-Gómez, Ángel M. Wärnberg, Julia Martínez, Alfredo J. Serra-Majem, Lluís Estruch, Ramon Muñoz-Garach, Araceli Lapetra, José Pintó, Xavier Tur, Josep A. Garcia-Rios, Antonio Bueno-Cavanillas, Aurora Delgado-Rodríguez, Miguel Matía-Martín, Pilar Daimiel, Lidia Martín-Sánchez, Vicente Vidal, Josep Vázquez, Clotilde Ros, Emilio Ruiz-Canela, Miguel Bulló, Mónica Sorli, Jose V. Quifer, Mireia Colom, Antoni Oncina-Canovas, Alejandro Tojal-Sierra, Lucas Barón-López, Javier Pérez-Farinós, Napoleón Abete, Itziar Sanchez-Villegas, Almudena Casas, Rosa Fernández-Garcia, José C. Santos-Lozano, José M. Corbella, Emili del M. Bibiloni, Maria Diez-Espino, Javier Asensio, Eva M. Torras, Laura Morey, Marga Compañ-Gabucio, Laura Salaverria-Lete, Itziar Cenoz-Osinaga, Juan C. Castañer, Olga Salas-Salvadó, Jordi |
author_facet | Papandreou, Christopher Babio, Nancy Díaz-López, Andrés Martínez-González, Miguel Á. Becerra-Tomas, Nerea Corella, Dolores Schröder, Helmut Romaguera, Dora Vioque, Jesús Alonso-Gómez, Ángel M. Wärnberg, Julia Martínez, Alfredo J. Serra-Majem, Lluís Estruch, Ramon Muñoz-Garach, Araceli Lapetra, José Pintó, Xavier Tur, Josep A. Garcia-Rios, Antonio Bueno-Cavanillas, Aurora Delgado-Rodríguez, Miguel Matía-Martín, Pilar Daimiel, Lidia Martín-Sánchez, Vicente Vidal, Josep Vázquez, Clotilde Ros, Emilio Ruiz-Canela, Miguel Bulló, Mónica Sorli, Jose V. Quifer, Mireia Colom, Antoni Oncina-Canovas, Alejandro Tojal-Sierra, Lucas Barón-López, Javier Pérez-Farinós, Napoleón Abete, Itziar Sanchez-Villegas, Almudena Casas, Rosa Fernández-Garcia, José C. Santos-Lozano, José M. Corbella, Emili del M. Bibiloni, Maria Diez-Espino, Javier Asensio, Eva M. Torras, Laura Morey, Marga Compañ-Gabucio, Laura Salaverria-Lete, Itziar Cenoz-Osinaga, Juan C. Castañer, Olga Salas-Salvadó, Jordi |
author_sort | Papandreou, Christopher |
collection | PubMed |
description | The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndrome in the (Prevención con Dieta Mediterránea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations (β = −0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each 1-hour increment in sleep duration was inversely associated with SUA to creatinine ratio (β = −0.15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio. |
format | Online Article Text |
id | pubmed-6521014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65210142019-05-31 Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk Papandreou, Christopher Babio, Nancy Díaz-López, Andrés Martínez-González, Miguel Á. Becerra-Tomas, Nerea Corella, Dolores Schröder, Helmut Romaguera, Dora Vioque, Jesús Alonso-Gómez, Ángel M. Wärnberg, Julia Martínez, Alfredo J. Serra-Majem, Lluís Estruch, Ramon Muñoz-Garach, Araceli Lapetra, José Pintó, Xavier Tur, Josep A. Garcia-Rios, Antonio Bueno-Cavanillas, Aurora Delgado-Rodríguez, Miguel Matía-Martín, Pilar Daimiel, Lidia Martín-Sánchez, Vicente Vidal, Josep Vázquez, Clotilde Ros, Emilio Ruiz-Canela, Miguel Bulló, Mónica Sorli, Jose V. Quifer, Mireia Colom, Antoni Oncina-Canovas, Alejandro Tojal-Sierra, Lucas Barón-López, Javier Pérez-Farinós, Napoleón Abete, Itziar Sanchez-Villegas, Almudena Casas, Rosa Fernández-Garcia, José C. Santos-Lozano, José M. Corbella, Emili del M. Bibiloni, Maria Diez-Espino, Javier Asensio, Eva M. Torras, Laura Morey, Marga Compañ-Gabucio, Laura Salaverria-Lete, Itziar Cenoz-Osinaga, Juan C. Castañer, Olga Salas-Salvadó, Jordi Nutrients Communication The aim of the study was to evaluate sleep duration and sleep variability in relation to serum uric acid (SUA) concentrations and SUA to creatinine ratio. This is a cross-sectional analysis of baseline data from 1842 elderly participants with overweight/obesity and metabolic syndrome in the (Prevención con Dieta Mediterránea) PREDIMED-Plus trial. Accelerometry-derived sleep duration and sleep variability were measured. Linear regression models were fitted to examine the aforementioned associations. A 1 hour/night increment in sleep duration was inversely associated with SUA concentrations (β = −0.07, p = 0.047). Further adjustment for leukocytes attenuated this association (p = 0.050). Each 1-hour increment in sleep duration was inversely associated with SUA to creatinine ratio (β = −0.15, p = 0.001). The findings of this study suggest that longer sleep duration is associated with lower SUA concentrations and lower SUA to creatinine ratio. MDPI 2019-04-01 /pmc/articles/PMC6521014/ /pubmed/30939748 http://dx.doi.org/10.3390/nu11040761 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Papandreou, Christopher Babio, Nancy Díaz-López, Andrés Martínez-González, Miguel Á. Becerra-Tomas, Nerea Corella, Dolores Schröder, Helmut Romaguera, Dora Vioque, Jesús Alonso-Gómez, Ángel M. Wärnberg, Julia Martínez, Alfredo J. Serra-Majem, Lluís Estruch, Ramon Muñoz-Garach, Araceli Lapetra, José Pintó, Xavier Tur, Josep A. Garcia-Rios, Antonio Bueno-Cavanillas, Aurora Delgado-Rodríguez, Miguel Matía-Martín, Pilar Daimiel, Lidia Martín-Sánchez, Vicente Vidal, Josep Vázquez, Clotilde Ros, Emilio Ruiz-Canela, Miguel Bulló, Mónica Sorli, Jose V. Quifer, Mireia Colom, Antoni Oncina-Canovas, Alejandro Tojal-Sierra, Lucas Barón-López, Javier Pérez-Farinós, Napoleón Abete, Itziar Sanchez-Villegas, Almudena Casas, Rosa Fernández-Garcia, José C. Santos-Lozano, José M. Corbella, Emili del M. Bibiloni, Maria Diez-Espino, Javier Asensio, Eva M. Torras, Laura Morey, Marga Compañ-Gabucio, Laura Salaverria-Lete, Itziar Cenoz-Osinaga, Juan C. Castañer, Olga Salas-Salvadó, Jordi Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk |
title | Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk |
title_full | Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk |
title_fullStr | Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk |
title_full_unstemmed | Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk |
title_short | Sleep Duration is Inversely Associated with Serum Uric Acid Concentrations and Uric Acid to Creatinine Ratio in an Elderly Mediterranean Population at High Cardiovascular Risk |
title_sort | sleep duration is inversely associated with serum uric acid concentrations and uric acid to creatinine ratio in an elderly mediterranean population at high cardiovascular risk |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521014/ https://www.ncbi.nlm.nih.gov/pubmed/30939748 http://dx.doi.org/10.3390/nu11040761 |
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