Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis

The transcription factor USF2 is supposed to have an important role in tumor development. However, the regulatory mechanisms contributing to the function of USF2 are largely unknown. Cyclin-dependent kinase 5 (CDK5) seems to be of importance since high levels of CDK5 were found in different cancers...

Descripción completa

Detalles Bibliográficos
Autores principales: Chi, Tabughang Franklin, Horbach, Tina, Götz, Claudia, Kietzmann, Thomas, Dimova, Elitsa Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521020/
https://www.ncbi.nlm.nih.gov/pubmed/31013770
http://dx.doi.org/10.3390/cancers11040523
_version_ 1783418860197642240
author Chi, Tabughang Franklin
Horbach, Tina
Götz, Claudia
Kietzmann, Thomas
Dimova, Elitsa Y.
author_facet Chi, Tabughang Franklin
Horbach, Tina
Götz, Claudia
Kietzmann, Thomas
Dimova, Elitsa Y.
author_sort Chi, Tabughang Franklin
collection PubMed
description The transcription factor USF2 is supposed to have an important role in tumor development. However, the regulatory mechanisms contributing to the function of USF2 are largely unknown. Cyclin-dependent kinase 5 (CDK5) seems to be of importance since high levels of CDK5 were found in different cancers associated with high USF2 expression. Here, we identified USF2 as a phosphorylation target of CDK5. USF2 is phosphorylated by CDK5 at two serine residues, serine 155 and serine 222. Further, phosphorylation of USF2 at these residues was shown to stabilize the protein and to regulate cellular growth and migration. Altogether, these results delineate the importance of the CDK5-USF2 interplay in cancer cells.
format Online
Article
Text
id pubmed-6521020
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-65210202019-05-31 Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis Chi, Tabughang Franklin Horbach, Tina Götz, Claudia Kietzmann, Thomas Dimova, Elitsa Y. Cancers (Basel) Article The transcription factor USF2 is supposed to have an important role in tumor development. However, the regulatory mechanisms contributing to the function of USF2 are largely unknown. Cyclin-dependent kinase 5 (CDK5) seems to be of importance since high levels of CDK5 were found in different cancers associated with high USF2 expression. Here, we identified USF2 as a phosphorylation target of CDK5. USF2 is phosphorylated by CDK5 at two serine residues, serine 155 and serine 222. Further, phosphorylation of USF2 at these residues was shown to stabilize the protein and to regulate cellular growth and migration. Altogether, these results delineate the importance of the CDK5-USF2 interplay in cancer cells. MDPI 2019-04-12 /pmc/articles/PMC6521020/ /pubmed/31013770 http://dx.doi.org/10.3390/cancers11040523 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chi, Tabughang Franklin
Horbach, Tina
Götz, Claudia
Kietzmann, Thomas
Dimova, Elitsa Y.
Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis
title Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis
title_full Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis
title_fullStr Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis
title_full_unstemmed Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis
title_short Cyclin-Dependent Kinase 5 (CDK5)-Mediated Phosphorylation of Upstream Stimulatory Factor 2 (USF2) Contributes to Carcinogenesis
title_sort cyclin-dependent kinase 5 (cdk5)-mediated phosphorylation of upstream stimulatory factor 2 (usf2) contributes to carcinogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521020/
https://www.ncbi.nlm.nih.gov/pubmed/31013770
http://dx.doi.org/10.3390/cancers11040523
work_keys_str_mv AT chitabughangfranklin cyclindependentkinase5cdk5mediatedphosphorylationofupstreamstimulatoryfactor2usf2contributestocarcinogenesis
AT horbachtina cyclindependentkinase5cdk5mediatedphosphorylationofupstreamstimulatoryfactor2usf2contributestocarcinogenesis
AT gotzclaudia cyclindependentkinase5cdk5mediatedphosphorylationofupstreamstimulatoryfactor2usf2contributestocarcinogenesis
AT kietzmannthomas cyclindependentkinase5cdk5mediatedphosphorylationofupstreamstimulatoryfactor2usf2contributestocarcinogenesis
AT dimovaelitsay cyclindependentkinase5cdk5mediatedphosphorylationofupstreamstimulatoryfactor2usf2contributestocarcinogenesis

Ejemplares similares