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Calcium Ions Stimulate the Hyperphosphorylation of Tau by Activating Microsomal Prostaglandin E Synthase 1

Alzheimer’s disease (AD) is reportedly associated with the accumulation of calcium ions (Ca(2+)), and this accumulation is responsible for the phosphorylation of tau. Although several lines of evidence demonstrate the above phenomenon, the inherent mechanisms remain unknown. Using APP/PS1 Tg mice an...

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Detalles Bibliográficos
Autores principales:	Cao, Long-Long, Guan, Pei-Pei, Liang, Yun-Yue, Huang, Xue-Shi, Wang, Pu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521221/ https://www.ncbi.nlm.nih.gov/pubmed/31143112 http://dx.doi.org/10.3389/fnagi.2019.00108

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