Cargando…
The Edible Insect Gryllus bimaculatus Protects against Gut-Derived Inflammatory Responses and Liver Damage in Mice after Acute Alcohol Exposure
Accumulation of reactive oxygen species (ROS) in response to excess alcohol exposure is a major cause of gut barrier disruption and lipopolysaccharide (LPS)-induced hepatic inflammation, as well as liver steatosis and apoptosis. This study was designed to investigate protective effects of the cricke...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521266/ https://www.ncbi.nlm.nih.gov/pubmed/30995745 http://dx.doi.org/10.3390/nu11040857 |
_version_ | 1783418917703647232 |
---|---|
author | Hwang, Bo Byeol Chang, Moon Han Lee, Jin Hyup Heo, Wan Kim, Jae Kyeom Pan, Jeong Hoon Kim, Young Jun Kim, Jun Ho |
author_facet | Hwang, Bo Byeol Chang, Moon Han Lee, Jin Hyup Heo, Wan Kim, Jae Kyeom Pan, Jeong Hoon Kim, Young Jun Kim, Jun Ho |
author_sort | Hwang, Bo Byeol |
collection | PubMed |
description | Accumulation of reactive oxygen species (ROS) in response to excess alcohol exposure is a major cause of gut barrier disruption and lipopolysaccharide (LPS)-induced hepatic inflammation, as well as liver steatosis and apoptosis. This study was designed to investigate protective effects of the cricket Gryllus bimaculatus, an edible insect recognized by the Korea Food and Drug Administration, against acute alcoholic liver damage in mice. Administration of G. bimaculatus extracts (GBE) attenuated alcohol-induced steatosis and apoptotic responses in the liver and intestinal permeability to bacterial endotoxin. These protective effects were associated with suppression of ROS-mediated oxidative stress in both the liver and small intestine. Furthermore, in vivo and in vitro studies revealed that GBE inhibits LPS-induced Kupffer cell activation and subsequent inflammatory signaling. Importantly, the protective effects of GBE were more potent than those of silymarin, a known therapeutic agent for alcoholic liver diseases. |
format | Online Article Text |
id | pubmed-6521266 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65212662019-05-31 The Edible Insect Gryllus bimaculatus Protects against Gut-Derived Inflammatory Responses and Liver Damage in Mice after Acute Alcohol Exposure Hwang, Bo Byeol Chang, Moon Han Lee, Jin Hyup Heo, Wan Kim, Jae Kyeom Pan, Jeong Hoon Kim, Young Jun Kim, Jun Ho Nutrients Article Accumulation of reactive oxygen species (ROS) in response to excess alcohol exposure is a major cause of gut barrier disruption and lipopolysaccharide (LPS)-induced hepatic inflammation, as well as liver steatosis and apoptosis. This study was designed to investigate protective effects of the cricket Gryllus bimaculatus, an edible insect recognized by the Korea Food and Drug Administration, against acute alcoholic liver damage in mice. Administration of G. bimaculatus extracts (GBE) attenuated alcohol-induced steatosis and apoptotic responses in the liver and intestinal permeability to bacterial endotoxin. These protective effects were associated with suppression of ROS-mediated oxidative stress in both the liver and small intestine. Furthermore, in vivo and in vitro studies revealed that GBE inhibits LPS-induced Kupffer cell activation and subsequent inflammatory signaling. Importantly, the protective effects of GBE were more potent than those of silymarin, a known therapeutic agent for alcoholic liver diseases. MDPI 2019-04-16 /pmc/articles/PMC6521266/ /pubmed/30995745 http://dx.doi.org/10.3390/nu11040857 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hwang, Bo Byeol Chang, Moon Han Lee, Jin Hyup Heo, Wan Kim, Jae Kyeom Pan, Jeong Hoon Kim, Young Jun Kim, Jun Ho The Edible Insect Gryllus bimaculatus Protects against Gut-Derived Inflammatory Responses and Liver Damage in Mice after Acute Alcohol Exposure |
title | The Edible Insect Gryllus bimaculatus Protects against Gut-Derived Inflammatory Responses and Liver Damage in Mice after Acute Alcohol Exposure |
title_full | The Edible Insect Gryllus bimaculatus Protects against Gut-Derived Inflammatory Responses and Liver Damage in Mice after Acute Alcohol Exposure |
title_fullStr | The Edible Insect Gryllus bimaculatus Protects against Gut-Derived Inflammatory Responses and Liver Damage in Mice after Acute Alcohol Exposure |
title_full_unstemmed | The Edible Insect Gryllus bimaculatus Protects against Gut-Derived Inflammatory Responses and Liver Damage in Mice after Acute Alcohol Exposure |
title_short | The Edible Insect Gryllus bimaculatus Protects against Gut-Derived Inflammatory Responses and Liver Damage in Mice after Acute Alcohol Exposure |
title_sort | edible insect gryllus bimaculatus protects against gut-derived inflammatory responses and liver damage in mice after acute alcohol exposure |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521266/ https://www.ncbi.nlm.nih.gov/pubmed/30995745 http://dx.doi.org/10.3390/nu11040857 |
work_keys_str_mv | AT hwangbobyeol theedibleinsectgryllusbimaculatusprotectsagainstgutderivedinflammatoryresponsesandliverdamageinmiceafteracutealcoholexposure AT changmoonhan theedibleinsectgryllusbimaculatusprotectsagainstgutderivedinflammatoryresponsesandliverdamageinmiceafteracutealcoholexposure AT leejinhyup theedibleinsectgryllusbimaculatusprotectsagainstgutderivedinflammatoryresponsesandliverdamageinmiceafteracutealcoholexposure AT heowan theedibleinsectgryllusbimaculatusprotectsagainstgutderivedinflammatoryresponsesandliverdamageinmiceafteracutealcoholexposure AT kimjaekyeom theedibleinsectgryllusbimaculatusprotectsagainstgutderivedinflammatoryresponsesandliverdamageinmiceafteracutealcoholexposure AT panjeonghoon theedibleinsectgryllusbimaculatusprotectsagainstgutderivedinflammatoryresponsesandliverdamageinmiceafteracutealcoholexposure AT kimyoungjun theedibleinsectgryllusbimaculatusprotectsagainstgutderivedinflammatoryresponsesandliverdamageinmiceafteracutealcoholexposure AT kimjunho theedibleinsectgryllusbimaculatusprotectsagainstgutderivedinflammatoryresponsesandliverdamageinmiceafteracutealcoholexposure AT hwangbobyeol edibleinsectgryllusbimaculatusprotectsagainstgutderivedinflammatoryresponsesandliverdamageinmiceafteracutealcoholexposure AT changmoonhan edibleinsectgryllusbimaculatusprotectsagainstgutderivedinflammatoryresponsesandliverdamageinmiceafteracutealcoholexposure AT leejinhyup edibleinsectgryllusbimaculatusprotectsagainstgutderivedinflammatoryresponsesandliverdamageinmiceafteracutealcoholexposure AT heowan edibleinsectgryllusbimaculatusprotectsagainstgutderivedinflammatoryresponsesandliverdamageinmiceafteracutealcoholexposure AT kimjaekyeom edibleinsectgryllusbimaculatusprotectsagainstgutderivedinflammatoryresponsesandliverdamageinmiceafteracutealcoholexposure AT panjeonghoon edibleinsectgryllusbimaculatusprotectsagainstgutderivedinflammatoryresponsesandliverdamageinmiceafteracutealcoholexposure AT kimyoungjun edibleinsectgryllusbimaculatusprotectsagainstgutderivedinflammatoryresponsesandliverdamageinmiceafteracutealcoholexposure AT kimjunho edibleinsectgryllusbimaculatusprotectsagainstgutderivedinflammatoryresponsesandliverdamageinmiceafteracutealcoholexposure |