The Role of Platelets in Cancer Pathophysiology: Focus on Malignant Glioma

The link between thrombocytosis and malignancy has been well known for many years and its associations with worse outcomes have been reported mainly for solid tumors. Besides measuring platelet count, it has become popular to assess platelet function in the context of malignant diseases during the l...

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Autores principales: Marx, Sascha, Xiao, Yong, Baschin, Marcel, Splittstöhser, Maximilian, Altmann, Robert, Moritz, Eileen, Jedlitschky, Gabriele, Bien-Möller, Sandra, Schroeder, Henry W.S., Rauch, Bernhard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521321/
https://www.ncbi.nlm.nih.gov/pubmed/31013620
http://dx.doi.org/10.3390/cancers11040569
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author Marx, Sascha
Xiao, Yong
Baschin, Marcel
Splittstöhser, Maximilian
Altmann, Robert
Moritz, Eileen
Jedlitschky, Gabriele
Bien-Möller, Sandra
Schroeder, Henry W.S.
Rauch, Bernhard H.
author_facet Marx, Sascha
Xiao, Yong
Baschin, Marcel
Splittstöhser, Maximilian
Altmann, Robert
Moritz, Eileen
Jedlitschky, Gabriele
Bien-Möller, Sandra
Schroeder, Henry W.S.
Rauch, Bernhard H.
author_sort Marx, Sascha
collection PubMed
description The link between thrombocytosis and malignancy has been well known for many years and its associations with worse outcomes have been reported mainly for solid tumors. Besides measuring platelet count, it has become popular to assess platelet function in the context of malignant diseases during the last decade. Malignant gliomas differ tremendously from malignancies outside the central nervous system because they virtually never form distant metastases. This review summarizes the current understanding of the platelet–immune cell communication and its potential role in glioma resistance and progression. Particularly, we focus on platelet-derived proinflammatory modulators, such as sphingosine-1-phosphate (S1P). The multifaceted interaction with immune cells puts the platelet into an interesting perspective regarding the recent advances in immunotherapeutic approaches in malignant glioma.
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spelling pubmed-65213212019-05-31 The Role of Platelets in Cancer Pathophysiology: Focus on Malignant Glioma Marx, Sascha Xiao, Yong Baschin, Marcel Splittstöhser, Maximilian Altmann, Robert Moritz, Eileen Jedlitschky, Gabriele Bien-Möller, Sandra Schroeder, Henry W.S. Rauch, Bernhard H. Cancers (Basel) Review The link between thrombocytosis and malignancy has been well known for many years and its associations with worse outcomes have been reported mainly for solid tumors. Besides measuring platelet count, it has become popular to assess platelet function in the context of malignant diseases during the last decade. Malignant gliomas differ tremendously from malignancies outside the central nervous system because they virtually never form distant metastases. This review summarizes the current understanding of the platelet–immune cell communication and its potential role in glioma resistance and progression. Particularly, we focus on platelet-derived proinflammatory modulators, such as sphingosine-1-phosphate (S1P). The multifaceted interaction with immune cells puts the platelet into an interesting perspective regarding the recent advances in immunotherapeutic approaches in malignant glioma. MDPI 2019-04-22 /pmc/articles/PMC6521321/ /pubmed/31013620 http://dx.doi.org/10.3390/cancers11040569 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Marx, Sascha
Xiao, Yong
Baschin, Marcel
Splittstöhser, Maximilian
Altmann, Robert
Moritz, Eileen
Jedlitschky, Gabriele
Bien-Möller, Sandra
Schroeder, Henry W.S.
Rauch, Bernhard H.
The Role of Platelets in Cancer Pathophysiology: Focus on Malignant Glioma
title The Role of Platelets in Cancer Pathophysiology: Focus on Malignant Glioma
title_full The Role of Platelets in Cancer Pathophysiology: Focus on Malignant Glioma
title_fullStr The Role of Platelets in Cancer Pathophysiology: Focus on Malignant Glioma
title_full_unstemmed The Role of Platelets in Cancer Pathophysiology: Focus on Malignant Glioma
title_short The Role of Platelets in Cancer Pathophysiology: Focus on Malignant Glioma
title_sort role of platelets in cancer pathophysiology: focus on malignant glioma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521321/
https://www.ncbi.nlm.nih.gov/pubmed/31013620
http://dx.doi.org/10.3390/cancers11040569
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