Next-generation genome annotation: we still struggle to get it right

While the genome sequencing revolution has led to the sequencing and assembly of many thousands of new genomes, genome annotation still uses very nearly the same technology that we have used for the past two decades. The sheer number of genomes necessitates the use of fully automated procedures for...

Descripción completa

Detalles Bibliográficos
Autor principal: Salzberg, Steven L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521345/
https://www.ncbi.nlm.nih.gov/pubmed/31097009
http://dx.doi.org/10.1186/s13059-019-1715-2
_version_ 1783418936181653504
author Salzberg, Steven L.
author_facet Salzberg, Steven L.
author_sort Salzberg, Steven L.
collection PubMed
description While the genome sequencing revolution has led to the sequencing and assembly of many thousands of new genomes, genome annotation still uses very nearly the same technology that we have used for the past two decades. The sheer number of genomes necessitates the use of fully automated procedures for annotation, but errors in annotation are just as prevalent as they were in the past, if not more so. How are we to solve this growing problem?
format Online
Article
Text
id pubmed-6521345
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-65213452019-05-23 Next-generation genome annotation: we still struggle to get it right Salzberg, Steven L. Genome Biol Editorial While the genome sequencing revolution has led to the sequencing and assembly of many thousands of new genomes, genome annotation still uses very nearly the same technology that we have used for the past two decades. The sheer number of genomes necessitates the use of fully automated procedures for annotation, but errors in annotation are just as prevalent as they were in the past, if not more so. How are we to solve this growing problem? BioMed Central 2019-05-16 /pmc/articles/PMC6521345/ /pubmed/31097009 http://dx.doi.org/10.1186/s13059-019-1715-2 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Editorial
Salzberg, Steven L.
Next-generation genome annotation: we still struggle to get it right
title Next-generation genome annotation: we still struggle to get it right
title_full Next-generation genome annotation: we still struggle to get it right
title_fullStr Next-generation genome annotation: we still struggle to get it right
title_full_unstemmed Next-generation genome annotation: we still struggle to get it right
title_short Next-generation genome annotation: we still struggle to get it right
title_sort next-generation genome annotation: we still struggle to get it right
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521345/
https://www.ncbi.nlm.nih.gov/pubmed/31097009
http://dx.doi.org/10.1186/s13059-019-1715-2
work_keys_str_mv AT salzbergstevenl nextgenerationgenomeannotationwestillstruggletogetitright

Ejemplares similares