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Prognosis of Small Cell Lung Cancer with Idiopathic Pulmonary Fibrosis: Assessment according to GAP Stage

INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) is an independent risk factor for lung cancer development, and small cell lung cancer (SCLC) comprises 15-20% of lung cancers with IPF. The objective of this study was to investigate survival outcomes and treatment-related complications according to...

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Autores principales: Song, Myung Jin, Lim, Sung Yoon, Park, Jong Sun, Yoon, Ho il, Lee, Jae-Ho, Kim, Song Yee, Jung, Ji Ye, Kang, Young Ae, Park, Moo Suk, Kim, Young Sam, Chang, Joon, Lee, Sang Hoon, Lee, Choon-Taek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521435/
https://www.ncbi.nlm.nih.gov/pubmed/31186636
http://dx.doi.org/10.1155/2019/5437390
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author Song, Myung Jin
Lim, Sung Yoon
Park, Jong Sun
Yoon, Ho il
Lee, Jae-Ho
Kim, Song Yee
Jung, Ji Ye
Kang, Young Ae
Park, Moo Suk
Kim, Young Sam
Chang, Joon
Lee, Sang Hoon
Lee, Choon-Taek
author_facet Song, Myung Jin
Lim, Sung Yoon
Park, Jong Sun
Yoon, Ho il
Lee, Jae-Ho
Kim, Song Yee
Jung, Ji Ye
Kang, Young Ae
Park, Moo Suk
Kim, Young Sam
Chang, Joon
Lee, Sang Hoon
Lee, Choon-Taek
author_sort Song, Myung Jin
collection PubMed
description INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) is an independent risk factor for lung cancer development, and small cell lung cancer (SCLC) comprises 15-20% of lung cancers with IPF. The objective of this study was to investigate survival outcomes and treatment-related complications according to GAP (gender, age, and physiology) stage in patients having SCLC with IPF (SCLC-IPF). MATERIALS AND METHODS: Retrospectively collected data of SCLC-IPF patients from two tertiary care university hospitals in South Korea were reviewed. A total of 59 SCLC-IPF patients were identified and categorized according to GAP stage, which was proposed by Ley et al. in 2012 to predict the prognosis of IPF. Survival outcomes and treatment-related complications were compared between the two groups. RESULTS: In a total of 59 patients, the median age was 71 years and 58 (98.3%) were male. In a comparison of the median overall survival (OS) according to GAP stage, median OS of the advanced GAP stage group was significantly shorter than median OS of GAP stage I group (7.1 months vs. 16.1 months; p = 0.002). Treatment-related complications occurred more frequently in the advanced GAP stage group; advanced GAP stage was the only predictor that exhibited a significant association with the incidence of acute exacerbation of IPF. CONCLUSIONS: Inferior survival outcome and higher incidence of treatment-related pulmonary toxicities were noted in the advanced GAP stage group. Furthermore, advanced GAP stage was the only predictor of treatment-related acute exacerbation of IPF. Physicians should thus consider GAP stage, which reflects the severity of IPF, during treatment of SCLC-IPF.
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spelling pubmed-65214352019-06-11 Prognosis of Small Cell Lung Cancer with Idiopathic Pulmonary Fibrosis: Assessment according to GAP Stage Song, Myung Jin Lim, Sung Yoon Park, Jong Sun Yoon, Ho il Lee, Jae-Ho Kim, Song Yee Jung, Ji Ye Kang, Young Ae Park, Moo Suk Kim, Young Sam Chang, Joon Lee, Sang Hoon Lee, Choon-Taek J Oncol Research Article INTRODUCTION: Idiopathic pulmonary fibrosis (IPF) is an independent risk factor for lung cancer development, and small cell lung cancer (SCLC) comprises 15-20% of lung cancers with IPF. The objective of this study was to investigate survival outcomes and treatment-related complications according to GAP (gender, age, and physiology) stage in patients having SCLC with IPF (SCLC-IPF). MATERIALS AND METHODS: Retrospectively collected data of SCLC-IPF patients from two tertiary care university hospitals in South Korea were reviewed. A total of 59 SCLC-IPF patients were identified and categorized according to GAP stage, which was proposed by Ley et al. in 2012 to predict the prognosis of IPF. Survival outcomes and treatment-related complications were compared between the two groups. RESULTS: In a total of 59 patients, the median age was 71 years and 58 (98.3%) were male. In a comparison of the median overall survival (OS) according to GAP stage, median OS of the advanced GAP stage group was significantly shorter than median OS of GAP stage I group (7.1 months vs. 16.1 months; p = 0.002). Treatment-related complications occurred more frequently in the advanced GAP stage group; advanced GAP stage was the only predictor that exhibited a significant association with the incidence of acute exacerbation of IPF. CONCLUSIONS: Inferior survival outcome and higher incidence of treatment-related pulmonary toxicities were noted in the advanced GAP stage group. Furthermore, advanced GAP stage was the only predictor of treatment-related acute exacerbation of IPF. Physicians should thus consider GAP stage, which reflects the severity of IPF, during treatment of SCLC-IPF. Hindawi 2019-05-02 /pmc/articles/PMC6521435/ /pubmed/31186636 http://dx.doi.org/10.1155/2019/5437390 Text en Copyright © 2019 Myung Jin Song et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Song, Myung Jin
Lim, Sung Yoon
Park, Jong Sun
Yoon, Ho il
Lee, Jae-Ho
Kim, Song Yee
Jung, Ji Ye
Kang, Young Ae
Park, Moo Suk
Kim, Young Sam
Chang, Joon
Lee, Sang Hoon
Lee, Choon-Taek
Prognosis of Small Cell Lung Cancer with Idiopathic Pulmonary Fibrosis: Assessment according to GAP Stage
title Prognosis of Small Cell Lung Cancer with Idiopathic Pulmonary Fibrosis: Assessment according to GAP Stage
title_full Prognosis of Small Cell Lung Cancer with Idiopathic Pulmonary Fibrosis: Assessment according to GAP Stage
title_fullStr Prognosis of Small Cell Lung Cancer with Idiopathic Pulmonary Fibrosis: Assessment according to GAP Stage
title_full_unstemmed Prognosis of Small Cell Lung Cancer with Idiopathic Pulmonary Fibrosis: Assessment according to GAP Stage
title_short Prognosis of Small Cell Lung Cancer with Idiopathic Pulmonary Fibrosis: Assessment according to GAP Stage
title_sort prognosis of small cell lung cancer with idiopathic pulmonary fibrosis: assessment according to gap stage
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521435/
https://www.ncbi.nlm.nih.gov/pubmed/31186636
http://dx.doi.org/10.1155/2019/5437390
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