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Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF-κB

In oriental medicine, mixtures of medical plants are always used as prescriptions for diseases. Natural products extracted from herbs have great potential antiaging effects. Previous studies and clinical trials have shown several critical functions of Erjingwan (EJW), such as nourishing Yin, kidney...

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Autores principales: Zhong, Hairong, Hong, Choyoung, Han, Zhouxin, Hwang, Seung Jin, Kim, Byunghyun, Xu, Zihang, Lee, Junmun, Hoon Kim, Ki, Jin, Mu Hyun, Zou, Chunpu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521471/
https://www.ncbi.nlm.nih.gov/pubmed/31186662
http://dx.doi.org/10.1155/2019/5976749
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author Zhong, Hairong
Hong, Choyoung
Han, Zhouxin
Hwang, Seung Jin
Kim, Byunghyun
Xu, Zihang
Lee, Junmun
Hoon Kim, Ki
Jin, Mu Hyun
Zou, Chunpu
author_facet Zhong, Hairong
Hong, Choyoung
Han, Zhouxin
Hwang, Seung Jin
Kim, Byunghyun
Xu, Zihang
Lee, Junmun
Hoon Kim, Ki
Jin, Mu Hyun
Zou, Chunpu
author_sort Zhong, Hairong
collection PubMed
description In oriental medicine, mixtures of medical plants are always used as prescriptions for diseases. Natural products extracted from herbs have great potential antiaging effects. Previous studies and clinical trials have shown several critical functions of Erjingwan (EJW), such as nourishing Yin, kidney tonifying and aging-resistance. We assumed that EJW extracts exerted the antiaging effects through nourishing Yin. We examined the antiaging effects of EJW extracts on healthy human skin by noninvasive measurements. Then we estimated the cell proliferation and DPPH radical scavenging rate. Western blotting analysis was used to determine the expressions of matrix metalloproteinase-1 (MMP-1), type I collagen (COL1A2), p-NF-κB, NF-κB, p-IκBα, IκBα, p-Nrf2, and HO-1. EJW extracts did not affect moisture content, TEWL and skin chroma, while it significantly improved skin glossiness and skin elasticity. Moreover, EJW extracts could downregulate the MMP1 expression and upregulate the COL1A2 expression. In addition, it promoted the Nrf2 pathway while it inhibited the NF-κB pathway. With the application of cream containing EJW extracts, the skin aging state was significantly improved. Furthermore, in vitro studies showed that EJW extracts contributed to the repair of skin after injury. Taken together, the antiaging effects of EJW extracts were related to its antioxidant and anti-inflammatory abilities.
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spelling pubmed-65214712019-06-11 Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF-κB Zhong, Hairong Hong, Choyoung Han, Zhouxin Hwang, Seung Jin Kim, Byunghyun Xu, Zihang Lee, Junmun Hoon Kim, Ki Jin, Mu Hyun Zou, Chunpu Evid Based Complement Alternat Med Research Article In oriental medicine, mixtures of medical plants are always used as prescriptions for diseases. Natural products extracted from herbs have great potential antiaging effects. Previous studies and clinical trials have shown several critical functions of Erjingwan (EJW), such as nourishing Yin, kidney tonifying and aging-resistance. We assumed that EJW extracts exerted the antiaging effects through nourishing Yin. We examined the antiaging effects of EJW extracts on healthy human skin by noninvasive measurements. Then we estimated the cell proliferation and DPPH radical scavenging rate. Western blotting analysis was used to determine the expressions of matrix metalloproteinase-1 (MMP-1), type I collagen (COL1A2), p-NF-κB, NF-κB, p-IκBα, IκBα, p-Nrf2, and HO-1. EJW extracts did not affect moisture content, TEWL and skin chroma, while it significantly improved skin glossiness and skin elasticity. Moreover, EJW extracts could downregulate the MMP1 expression and upregulate the COL1A2 expression. In addition, it promoted the Nrf2 pathway while it inhibited the NF-κB pathway. With the application of cream containing EJW extracts, the skin aging state was significantly improved. Furthermore, in vitro studies showed that EJW extracts contributed to the repair of skin after injury. Taken together, the antiaging effects of EJW extracts were related to its antioxidant and anti-inflammatory abilities. Hindawi 2019-05-02 /pmc/articles/PMC6521471/ /pubmed/31186662 http://dx.doi.org/10.1155/2019/5976749 Text en Copyright © 2019 Hairong Zhong et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhong, Hairong
Hong, Choyoung
Han, Zhouxin
Hwang, Seung Jin
Kim, Byunghyun
Xu, Zihang
Lee, Junmun
Hoon Kim, Ki
Jin, Mu Hyun
Zou, Chunpu
Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF-κB
title Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF-κB
title_full Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF-κB
title_fullStr Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF-κB
title_full_unstemmed Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF-κB
title_short Erjingwan Extracts Exert Antiaging Effects of Skin through Activating Nrf2 and Inhibiting NF-κB
title_sort erjingwan extracts exert antiaging effects of skin through activating nrf2 and inhibiting nf-κb
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521471/
https://www.ncbi.nlm.nih.gov/pubmed/31186662
http://dx.doi.org/10.1155/2019/5976749
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