The wind changed direction and the big river still flows: from EUPHRATES to TIGRIS

The overall result of the randomized controlled double-blinded trial for polymyxin B-immobilized fiber column on septic shock (EUPHRATES trial) was disappointing. However, post hoc analysis showed benefits for patients with certain Endotoxin Activity Assay (EAA) levels. Thus, the study will be repea...

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Detalles Bibliográficos
Autores principales: Iba, Toshiaki, Klein, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521478/
https://www.ncbi.nlm.nih.gov/pubmed/31131109
http://dx.doi.org/10.1186/s40560-019-0386-0
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author Iba, Toshiaki
Klein, David J.
author_facet Iba, Toshiaki
Klein, David J.
author_sort Iba, Toshiaki
collection PubMed
description The overall result of the randomized controlled double-blinded trial for polymyxin B-immobilized fiber column on septic shock (EUPHRATES trial) was disappointing. However, post hoc analysis showed benefits for patients with certain Endotoxin Activity Assay (EAA) levels. Thus, the study will be repeated, and the data will be added to the former trial. Using a precision medicine approach, eligibility criteria have been modified in TIGRIS to include patients with MODS score > 9 and EAA levels between 0.60 and 0.89. We are currently feeling the change in the wind as the rivers continue to flow towards PMX therapy for endotoxemic septic shock.
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spelling pubmed-65214782019-05-24 The wind changed direction and the big river still flows: from EUPHRATES to TIGRIS Iba, Toshiaki Klein, David J. J Intensive Care Letter to the Editor The overall result of the randomized controlled double-blinded trial for polymyxin B-immobilized fiber column on septic shock (EUPHRATES trial) was disappointing. However, post hoc analysis showed benefits for patients with certain Endotoxin Activity Assay (EAA) levels. Thus, the study will be repeated, and the data will be added to the former trial. Using a precision medicine approach, eligibility criteria have been modified in TIGRIS to include patients with MODS score > 9 and EAA levels between 0.60 and 0.89. We are currently feeling the change in the wind as the rivers continue to flow towards PMX therapy for endotoxemic septic shock. BioMed Central 2019-05-16 /pmc/articles/PMC6521478/ /pubmed/31131109 http://dx.doi.org/10.1186/s40560-019-0386-0 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Iba, Toshiaki
Klein, David J.
The wind changed direction and the big river still flows: from EUPHRATES to TIGRIS
title The wind changed direction and the big river still flows: from EUPHRATES to TIGRIS
title_full The wind changed direction and the big river still flows: from EUPHRATES to TIGRIS
title_fullStr The wind changed direction and the big river still flows: from EUPHRATES to TIGRIS
title_full_unstemmed The wind changed direction and the big river still flows: from EUPHRATES to TIGRIS
title_short The wind changed direction and the big river still flows: from EUPHRATES to TIGRIS
title_sort wind changed direction and the big river still flows: from euphrates to tigris
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521478/
https://www.ncbi.nlm.nih.gov/pubmed/31131109
http://dx.doi.org/10.1186/s40560-019-0386-0
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