RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer

Genetic polymorphisms in DNA repair genes may affect DNA repair efficiency and may contribute to the risk of developing cancer. The aim of our study was to investigate single nucleotide polymorphisms (SNPs) in RAD51 (rs2619679, rs2928140, and rs5030789) and XRCC3 (rs1799796) involved in DNA double-s...

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Autores principales: Nowacka-Zawisza, Maria, Raszkiewicz, Agata, Kwasiborski, Tomasz, Forma, Ewa, Bryś, Magdalena, Różański, Waldemar, Krajewska, Wanda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521534/
https://www.ncbi.nlm.nih.gov/pubmed/31186630
http://dx.doi.org/10.1155/2019/2976373
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author Nowacka-Zawisza, Maria
Raszkiewicz, Agata
Kwasiborski, Tomasz
Forma, Ewa
Bryś, Magdalena
Różański, Waldemar
Krajewska, Wanda M.
author_facet Nowacka-Zawisza, Maria
Raszkiewicz, Agata
Kwasiborski, Tomasz
Forma, Ewa
Bryś, Magdalena
Różański, Waldemar
Krajewska, Wanda M.
author_sort Nowacka-Zawisza, Maria
collection PubMed
description Genetic polymorphisms in DNA repair genes may affect DNA repair efficiency and may contribute to the risk of developing cancer. The aim of our study was to investigate single nucleotide polymorphisms (SNPs) in RAD51 (rs2619679, rs2928140, and rs5030789) and XRCC3 (rs1799796) involved in DNA double-strand break repair and their relationship to prostate cancer. The study group included 99 men diagnosed with prostate cancer and 205 cancer-free controls. SNP genotyping was performed using the PCR-RFLP method. A significant association was detected between RAD51 rs5030789 polymorphism and XRCC3 rs1799796 polymorphism and an increased risk of prostate cancer. Our results indicate that RAD51 and XRCC3 polymorphism may contribute to prostate cancer.
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spelling pubmed-65215342019-06-11 RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer Nowacka-Zawisza, Maria Raszkiewicz, Agata Kwasiborski, Tomasz Forma, Ewa Bryś, Magdalena Różański, Waldemar Krajewska, Wanda M. J Oncol Research Article Genetic polymorphisms in DNA repair genes may affect DNA repair efficiency and may contribute to the risk of developing cancer. The aim of our study was to investigate single nucleotide polymorphisms (SNPs) in RAD51 (rs2619679, rs2928140, and rs5030789) and XRCC3 (rs1799796) involved in DNA double-strand break repair and their relationship to prostate cancer. The study group included 99 men diagnosed with prostate cancer and 205 cancer-free controls. SNP genotyping was performed using the PCR-RFLP method. A significant association was detected between RAD51 rs5030789 polymorphism and XRCC3 rs1799796 polymorphism and an increased risk of prostate cancer. Our results indicate that RAD51 and XRCC3 polymorphism may contribute to prostate cancer. Hindawi 2019-05-02 /pmc/articles/PMC6521534/ /pubmed/31186630 http://dx.doi.org/10.1155/2019/2976373 Text en Copyright © 2019 Maria Nowacka-Zawisza et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nowacka-Zawisza, Maria
Raszkiewicz, Agata
Kwasiborski, Tomasz
Forma, Ewa
Bryś, Magdalena
Różański, Waldemar
Krajewska, Wanda M.
RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer
title RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer
title_full RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer
title_fullStr RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer
title_full_unstemmed RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer
title_short RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer
title_sort rad51 and xrcc3 polymorphisms are associated with increased risk of prostate cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521534/
https://www.ncbi.nlm.nih.gov/pubmed/31186630
http://dx.doi.org/10.1155/2019/2976373
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