Mitochondrially targeted p53 or DBD subdomain is superior to wild type p53 in ovarian cancer cells even with strong dominant negative mutant p53

BACKGROUND: While tumor suppressor p53 functions primarily as a transcription factor in the nucleus, cellular stress can cause p53 to translocate to the mitochondria and directly trigger a rapid apoptotic response. We have previously shown that fusing p53 (or its DNA binding domain, DBD, alone) to t...

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Detalles Bibliográficos
Autores principales: Lu, Phong, Vander Mause, Erica R., Redd Bowman, Katherine E., Brown, Sarah M., Ahne, Lisa, Lim, Carol S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521536/
https://www.ncbi.nlm.nih.gov/pubmed/31092272
http://dx.doi.org/10.1186/s13048-019-0516-2

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