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A Comparative Study of the Efficacy of Intravenous Benzylpenicillin and Intravenous Augmentin in the Empirical Management of Ludwig's Angina

BACKGROUND: Ludwig's angina is a potentially life-threatening condition characterized by bilateral cellulitis of the submandibular, submental, and sublingual spaces. Intravenous (I.V) penicillin G or amoxicillin-clavulanate (Augmentin) has been recommended for use as empirical management before...

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Autores principales: Boamah, Matthew Owusu, Saheeb, Birch Dauda, Parkins, Grace E., Nuamah, Isaac, Ndanu, Tom Akuetteh, Blankson, Paa-Kwesi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521646/
https://www.ncbi.nlm.nih.gov/pubmed/31070146
http://dx.doi.org/10.4103/aam.aam_22_18
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author Boamah, Matthew Owusu
Saheeb, Birch Dauda
Parkins, Grace E.
Nuamah, Isaac
Ndanu, Tom Akuetteh
Blankson, Paa-Kwesi
author_facet Boamah, Matthew Owusu
Saheeb, Birch Dauda
Parkins, Grace E.
Nuamah, Isaac
Ndanu, Tom Akuetteh
Blankson, Paa-Kwesi
author_sort Boamah, Matthew Owusu
collection PubMed
description BACKGROUND: Ludwig's angina is a potentially life-threatening condition characterized by bilateral cellulitis of the submandibular, submental, and sublingual spaces. Intravenous (I.V) penicillin G or amoxicillin-clavulanate (Augmentin) has been recommended for use as empirical management before obtaining culture and sensitivity results. AIM: The aim of this study was to compare the therapeutic efficacies and clinical outcomes of I.V benzylpenicillin with I.V Augmentin in the empirical management of Ludwig's angina. METHODS: This was a prospective randomized clinical study carried out to measure the rate of swelling reduction (using the lobar rate, Adam's rate, and interincisal distance) and other clinical parameters among the two drug groups (I.V penicillin G and Augmentin). Descriptive summaries of variables were generated, and Student's t-test was used to compare the mean outcomes of the two groups. RESULTS: A total of 26 individuals participated in the study, consisting of 46% (12) males and 54% (14) females. The participants ranged from 13 to 61 years with mean and median of 34.4 (±12.7) and 35 years, respectively. Only 8% of the cases of Ludwig's angina were not attributable to odontogenic factors, compared to 92% resulting from odontogenic causes. There was no significant difference in the efficacy of the two antibiotics used in this study. CONCLUSION: The efficacies and the clinical outcomes of the two antibiotics were similar. Benzylpenicillin is probably a suitable empirical alternative where Augmentin cannot be afforded, to reduce the mortality associated with the condition.
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spelling pubmed-65216462019-05-29 A Comparative Study of the Efficacy of Intravenous Benzylpenicillin and Intravenous Augmentin in the Empirical Management of Ludwig's Angina Boamah, Matthew Owusu Saheeb, Birch Dauda Parkins, Grace E. Nuamah, Isaac Ndanu, Tom Akuetteh Blankson, Paa-Kwesi Ann Afr Med Original Article BACKGROUND: Ludwig's angina is a potentially life-threatening condition characterized by bilateral cellulitis of the submandibular, submental, and sublingual spaces. Intravenous (I.V) penicillin G or amoxicillin-clavulanate (Augmentin) has been recommended for use as empirical management before obtaining culture and sensitivity results. AIM: The aim of this study was to compare the therapeutic efficacies and clinical outcomes of I.V benzylpenicillin with I.V Augmentin in the empirical management of Ludwig's angina. METHODS: This was a prospective randomized clinical study carried out to measure the rate of swelling reduction (using the lobar rate, Adam's rate, and interincisal distance) and other clinical parameters among the two drug groups (I.V penicillin G and Augmentin). Descriptive summaries of variables were generated, and Student's t-test was used to compare the mean outcomes of the two groups. RESULTS: A total of 26 individuals participated in the study, consisting of 46% (12) males and 54% (14) females. The participants ranged from 13 to 61 years with mean and median of 34.4 (±12.7) and 35 years, respectively. Only 8% of the cases of Ludwig's angina were not attributable to odontogenic factors, compared to 92% resulting from odontogenic causes. There was no significant difference in the efficacy of the two antibiotics used in this study. CONCLUSION: The efficacies and the clinical outcomes of the two antibiotics were similar. Benzylpenicillin is probably a suitable empirical alternative where Augmentin cannot be afforded, to reduce the mortality associated with the condition. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6521646/ /pubmed/31070146 http://dx.doi.org/10.4103/aam.aam_22_18 Text en Copyright: © 2019 Annals of African Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Boamah, Matthew Owusu
Saheeb, Birch Dauda
Parkins, Grace E.
Nuamah, Isaac
Ndanu, Tom Akuetteh
Blankson, Paa-Kwesi
A Comparative Study of the Efficacy of Intravenous Benzylpenicillin and Intravenous Augmentin in the Empirical Management of Ludwig's Angina
title A Comparative Study of the Efficacy of Intravenous Benzylpenicillin and Intravenous Augmentin in the Empirical Management of Ludwig's Angina
title_full A Comparative Study of the Efficacy of Intravenous Benzylpenicillin and Intravenous Augmentin in the Empirical Management of Ludwig's Angina
title_fullStr A Comparative Study of the Efficacy of Intravenous Benzylpenicillin and Intravenous Augmentin in the Empirical Management of Ludwig's Angina
title_full_unstemmed A Comparative Study of the Efficacy of Intravenous Benzylpenicillin and Intravenous Augmentin in the Empirical Management of Ludwig's Angina
title_short A Comparative Study of the Efficacy of Intravenous Benzylpenicillin and Intravenous Augmentin in the Empirical Management of Ludwig's Angina
title_sort comparative study of the efficacy of intravenous benzylpenicillin and intravenous augmentin in the empirical management of ludwig's angina
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521646/
https://www.ncbi.nlm.nih.gov/pubmed/31070146
http://dx.doi.org/10.4103/aam.aam_22_18
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