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Gender Differences in Dose of Erythropoietin to Maintain Hemoglobin Target in Hemodialysis Patients
Dialysis patients receiving erythropoietin (EPO) for anemia management are a challenge due to the significant interindividual variability in erythropoietic response. Our objective was to determine if there is a gender-dependent difference in the EPO doses required to maintain the hemoglobin (Hb) tar...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521763/ https://www.ncbi.nlm.nih.gov/pubmed/31142961 http://dx.doi.org/10.4103/ijn.IJN_124_18 |
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author | Coronado Daza, J. A. Cuchi, G. Urrútia |
author_facet | Coronado Daza, J. A. Cuchi, G. Urrútia |
author_sort | Coronado Daza, J. A. |
collection | PubMed |
description | Dialysis patients receiving erythropoietin (EPO) for anemia management are a challenge due to the significant interindividual variability in erythropoietic response. Our objective was to determine if there is a gender-dependent difference in the EPO doses required to maintain the hemoglobin (Hb) targets in adult patients undergoing hemodialysis. We conducted a historic cohort study with a 12-month follow-up. We include patients with the Hb target, normal serum albumin, and normal transferrin saturation index. Monthly data were gathered for the following: Hb level, EPO doses, and intravenous iron doses. In the 11 hemodialysis facilities included, 1844 patients were on hemodialysis. We considered 389 patients for follow-up, 190 of which were excluded mainly for failing to keep the Hb level in the established range. The final cohort for analysis included 141 men (70.9%) and 58 women (29.1%). At baseline, men weighed more than women (P < 0.001). At the end of the follow-up period, the EPO required to maintain Hb level between 10 and 13 g/dl was significantly higher in women in the monthly dose, weekly dose, and weekly EPO dose/patient weight, with no difference in the monthly iron dose. There was a significant association between female gender and the use of high EPO doses (odds ratio, 4.1; 95% confidence interval, 1.4–12.2; P = 0.01). Our study demonstrates that women require higher doses of EPO to achieve Hb targets. |
format | Online Article Text |
id | pubmed-6521763 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-65217632019-05-29 Gender Differences in Dose of Erythropoietin to Maintain Hemoglobin Target in Hemodialysis Patients Coronado Daza, J. A. Cuchi, G. Urrútia Indian J Nephrol Original Article Dialysis patients receiving erythropoietin (EPO) for anemia management are a challenge due to the significant interindividual variability in erythropoietic response. Our objective was to determine if there is a gender-dependent difference in the EPO doses required to maintain the hemoglobin (Hb) targets in adult patients undergoing hemodialysis. We conducted a historic cohort study with a 12-month follow-up. We include patients with the Hb target, normal serum albumin, and normal transferrin saturation index. Monthly data were gathered for the following: Hb level, EPO doses, and intravenous iron doses. In the 11 hemodialysis facilities included, 1844 patients were on hemodialysis. We considered 389 patients for follow-up, 190 of which were excluded mainly for failing to keep the Hb level in the established range. The final cohort for analysis included 141 men (70.9%) and 58 women (29.1%). At baseline, men weighed more than women (P < 0.001). At the end of the follow-up period, the EPO required to maintain Hb level between 10 and 13 g/dl was significantly higher in women in the monthly dose, weekly dose, and weekly EPO dose/patient weight, with no difference in the monthly iron dose. There was a significant association between female gender and the use of high EPO doses (odds ratio, 4.1; 95% confidence interval, 1.4–12.2; P = 0.01). Our study demonstrates that women require higher doses of EPO to achieve Hb targets. Wolters Kluwer - Medknow 2019 /pmc/articles/PMC6521763/ /pubmed/31142961 http://dx.doi.org/10.4103/ijn.IJN_124_18 Text en Copyright: © 2019 Indian Journal of Nephrology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Coronado Daza, J. A. Cuchi, G. Urrútia Gender Differences in Dose of Erythropoietin to Maintain Hemoglobin Target in Hemodialysis Patients |
title | Gender Differences in Dose of Erythropoietin to Maintain Hemoglobin Target in Hemodialysis Patients |
title_full | Gender Differences in Dose of Erythropoietin to Maintain Hemoglobin Target in Hemodialysis Patients |
title_fullStr | Gender Differences in Dose of Erythropoietin to Maintain Hemoglobin Target in Hemodialysis Patients |
title_full_unstemmed | Gender Differences in Dose of Erythropoietin to Maintain Hemoglobin Target in Hemodialysis Patients |
title_short | Gender Differences in Dose of Erythropoietin to Maintain Hemoglobin Target in Hemodialysis Patients |
title_sort | gender differences in dose of erythropoietin to maintain hemoglobin target in hemodialysis patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521763/ https://www.ncbi.nlm.nih.gov/pubmed/31142961 http://dx.doi.org/10.4103/ijn.IJN_124_18 |
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