The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression

ADP-ribosylation is a ubiquitous post-translational addition of either monomers or polymers of ADP-ribose to target proteins by ADP-ribosyltransferases, usually by interferon-inducible diphtheria toxin-like enzymes known as PARPs. While several PARPs have known antiviral activities, these activities...

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Detalles Bibliográficos
Autores principales: Grunewald, Matthew E., Chen, Yating, Kuny, Chad, Maejima, Takashi, Lease, Robert, Ferraris, Dana, Aikawa, Masanori, Sullivan, Christopher S., Perlman, Stanley, Fehr, Anthony R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6521996/
https://www.ncbi.nlm.nih.gov/pubmed/31095648
http://dx.doi.org/10.1371/journal.ppat.1007756

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