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Shared behavioral mechanisms underlie C. elegans aggregation and swarming
In complex biological systems, simple individual-level behavioral rules can give rise to emergent group-level behavior. While collective behavior has been well studied in cells and larger organisms, the mesoscopic scale is less understood, as it is unclear which sensory inputs and physical processes...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522220/ https://www.ncbi.nlm.nih.gov/pubmed/31021320 http://dx.doi.org/10.7554/eLife.43318 |
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author | Ding, Siyu Serena Schumacher, Linus J Javer, Avelino E Endres, Robert G Brown, André EX |
author_facet | Ding, Siyu Serena Schumacher, Linus J Javer, Avelino E Endres, Robert G Brown, André EX |
author_sort | Ding, Siyu Serena |
collection | PubMed |
description | In complex biological systems, simple individual-level behavioral rules can give rise to emergent group-level behavior. While collective behavior has been well studied in cells and larger organisms, the mesoscopic scale is less understood, as it is unclear which sensory inputs and physical processes matter a priori. Here, we investigate collective feeding in the roundworm C. elegans at this intermediate scale, using quantitative phenotyping and agent-based modeling to identify behavioral rules underlying both aggregation and swarming—a dynamic phenotype only observed at longer timescales. Using fluorescence multi-worm tracking, we quantify aggregation in terms of individual dynamics and population-level statistics. Then we use agent-based simulations and approximate Bayesian inference to identify three key behavioral rules for aggregation: cluster-edge reversals, a density-dependent switch between crawling speeds, and taxis towards neighboring worms. Our simulations suggest that swarming is simply driven by local food depletion but otherwise employs the same behavioral mechanisms as the initial aggregation. |
format | Online Article Text |
id | pubmed-6522220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-65222202019-05-20 Shared behavioral mechanisms underlie C. elegans aggregation and swarming Ding, Siyu Serena Schumacher, Linus J Javer, Avelino E Endres, Robert G Brown, André EX eLife Physics of Living Systems In complex biological systems, simple individual-level behavioral rules can give rise to emergent group-level behavior. While collective behavior has been well studied in cells and larger organisms, the mesoscopic scale is less understood, as it is unclear which sensory inputs and physical processes matter a priori. Here, we investigate collective feeding in the roundworm C. elegans at this intermediate scale, using quantitative phenotyping and agent-based modeling to identify behavioral rules underlying both aggregation and swarming—a dynamic phenotype only observed at longer timescales. Using fluorescence multi-worm tracking, we quantify aggregation in terms of individual dynamics and population-level statistics. Then we use agent-based simulations and approximate Bayesian inference to identify three key behavioral rules for aggregation: cluster-edge reversals, a density-dependent switch between crawling speeds, and taxis towards neighboring worms. Our simulations suggest that swarming is simply driven by local food depletion but otherwise employs the same behavioral mechanisms as the initial aggregation. eLife Sciences Publications, Ltd 2019-04-25 /pmc/articles/PMC6522220/ /pubmed/31021320 http://dx.doi.org/10.7554/eLife.43318 Text en © 2019, Ding et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Physics of Living Systems Ding, Siyu Serena Schumacher, Linus J Javer, Avelino E Endres, Robert G Brown, André EX Shared behavioral mechanisms underlie C. elegans aggregation and swarming |
title | Shared behavioral mechanisms underlie C. elegans aggregation and swarming |
title_full | Shared behavioral mechanisms underlie C. elegans aggregation and swarming |
title_fullStr | Shared behavioral mechanisms underlie C. elegans aggregation and swarming |
title_full_unstemmed | Shared behavioral mechanisms underlie C. elegans aggregation and swarming |
title_short | Shared behavioral mechanisms underlie C. elegans aggregation and swarming |
title_sort | shared behavioral mechanisms underlie c. elegans aggregation and swarming |
topic | Physics of Living Systems |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522220/ https://www.ncbi.nlm.nih.gov/pubmed/31021320 http://dx.doi.org/10.7554/eLife.43318 |
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