Identification of genetic variants associated with tacrolimus metabolism in kidney transplant recipients by extreme phenotype sampling and next generation sequencing

An extreme phenotype sampling (EPS) model with targeted next-generation sequencing (NGS) identified genetic variants associated with tacrolimus (Tac) metabolism in subjects from the Deterioration of Kidney Allograft Function (DeKAF) Genomics cohort which included 1,442 European Americans (EA) and 34...

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Detalles Bibliográficos
Autores principales: Dorr, Casey R., Wu, Baolin, Remmel, Rory P., Muthusamy, Amutha, Schladt, David P., Abrahante, Juan E., Guan, Weihua, Mannon, Roslyn B., Matas, Arthur J., Oetting, William S., Jacobson, Pamala A., Israni, Ajay K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522337/
https://www.ncbi.nlm.nih.gov/pubmed/30442921
http://dx.doi.org/10.1038/s41397-018-0063-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522337/
https://www.ncbi.nlm.nih.gov/pubmed/30442921
http://dx.doi.org/10.1038/s41397-018-0063-z

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