MEK inhibitors activate Wnt signalling and induce stem cell plasticity in colorectal cancer

In colorectal cancer (CRC), aberrant Wnt signalling is essential for tumorigenesis and maintenance of cancer stem cells. However, how other oncogenic pathways converge on Wnt signalling to modulate stem cell homeostasis in CRC currently remains poorly understood. Using large-scale compound screens i...

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Detalles Bibliográficos
Autores principales: Zhan, Tianzuo, Ambrosi, Giulia, Wandmacher, Anna Maxi, Rauscher, Benedikt, Betge, Johannes, Rindtorff, Niklas, Häussler, Ragna S., Hinsenkamp, Isabel, Bamberg, Leonhard, Hessling, Bernd, Müller-Decker, Karin, Erdmann, Gerrit, Burgermeister, Elke, Ebert, Matthias P., Boutros, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522484/
https://www.ncbi.nlm.nih.gov/pubmed/31097693
http://dx.doi.org/10.1038/s41467-019-09898-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522484/
https://www.ncbi.nlm.nih.gov/pubmed/31097693
http://dx.doi.org/10.1038/s41467-019-09898-0

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