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secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila

Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products. The hormones act through G-protein-coupled receptors to activate second messenger systems that in turn control the permeability of secretory epith...

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Autores principales: Feingold, Daniel, Knogler, Laura, Starc, Tanja, Drapeau, Pierre, O’Donnell, Michael J., Nilson, Laura A., Dent, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522505/
https://www.ncbi.nlm.nih.gov/pubmed/31097722
http://dx.doi.org/10.1038/s41598-019-42849-9
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author Feingold, Daniel
Knogler, Laura
Starc, Tanja
Drapeau, Pierre
O’Donnell, Michael J.
Nilson, Laura A.
Dent, Joseph A.
author_facet Feingold, Daniel
Knogler, Laura
Starc, Tanja
Drapeau, Pierre
O’Donnell, Michael J.
Nilson, Laura A.
Dent, Joseph A.
author_sort Feingold, Daniel
collection PubMed
description Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products. The hormones act through G-protein-coupled receptors to activate second messenger systems that in turn control the permeability of secretory epithelia to ions like chloride. In insects, the chloride channel mediating the effects of diuretic hormones was unknown. Surprisingly, we find a pentameric, cys-loop chloride channel, a type of channel normally associated with neurotransmission, mediating hormone-induced transepithelial chloride conductance. This discovery is important because: 1) it describes an unexpected role for pentameric receptors in the membrane permeability of secretory epithelial cells, and 2) it suggests that neurotransmitter-gated ion channels may have evolved from channels involved in secretion.
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spelling pubmed-65225052019-05-28 secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila Feingold, Daniel Knogler, Laura Starc, Tanja Drapeau, Pierre O’Donnell, Michael J. Nilson, Laura A. Dent, Joseph A. Sci Rep Article Organisms use circulating diuretic hormones to control water balance (osmolarity), thereby avoiding dehydration and managing excretion of waste products. The hormones act through G-protein-coupled receptors to activate second messenger systems that in turn control the permeability of secretory epithelia to ions like chloride. In insects, the chloride channel mediating the effects of diuretic hormones was unknown. Surprisingly, we find a pentameric, cys-loop chloride channel, a type of channel normally associated with neurotransmission, mediating hormone-induced transepithelial chloride conductance. This discovery is important because: 1) it describes an unexpected role for pentameric receptors in the membrane permeability of secretory epithelial cells, and 2) it suggests that neurotransmitter-gated ion channels may have evolved from channels involved in secretion. Nature Publishing Group UK 2019-05-16 /pmc/articles/PMC6522505/ /pubmed/31097722 http://dx.doi.org/10.1038/s41598-019-42849-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Feingold, Daniel
Knogler, Laura
Starc, Tanja
Drapeau, Pierre
O’Donnell, Michael J.
Nilson, Laura A.
Dent, Joseph A.
secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila
title secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila
title_full secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila
title_fullStr secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila
title_full_unstemmed secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila
title_short secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila
title_sort seccl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in drosophila
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522505/
https://www.ncbi.nlm.nih.gov/pubmed/31097722
http://dx.doi.org/10.1038/s41598-019-42849-9
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