Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening

Many gene fusions are reported in tumours and for most their role remains unknown. As fusions are used for diagnostic and prognostic purposes, and are targets for treatment, it is crucial to assess their function in cancer. To systematically investigate the role of fusions in tumour cell fitness, we...

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Detalles Bibliográficos
Autores principales: Picco, Gabriele, Chen, Elisabeth D., Alonso, Luz Garcia, Behan, Fiona M., Gonçalves, Emanuel, Bignell, Graham, Matchan, Angela, Fu, Beiyuan, Banerjee, Ruby, Anderson, Elizabeth, Butler, Adam, Benes, Cyril H., McDermott, Ultan, Dow, David, Iorio, Francesco, Stronach, Euan, Yang, Fengtang, Yusa, Kosuke, Saez-Rodriguez, Julio, Garnett, Mathew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522557/
https://www.ncbi.nlm.nih.gov/pubmed/31097696
http://dx.doi.org/10.1038/s41467-019-09940-1

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