Novel 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives produce anticancer efficacy in ovarian cancer in vitro

A novel series of 3-((2-chloroquinolin-3-yl)methylene)indolin-2-ones were synthesized, using the ‘molecular hybridization approach’ and evaluated for anticancer efficacy. Eleven 3-((2-chloroquinolin-3-yl)methylene)indolin-2-ones (LM01 to LM11) were synthesized and evaluated for in vitro cytotoxic ef...

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Autores principales: Karthikeyan, Chandrabose, Amawi, Haneen, Ashby, Charles R., Khare, Vishwa M., Jones, Veronica, Hari Narayana Moorthy, N.S., Trivedi, Piyush, Tiwari, Amit K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522656/
https://www.ncbi.nlm.nih.gov/pubmed/31193218
http://dx.doi.org/10.1016/j.heliyon.2019.e01603
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author Karthikeyan, Chandrabose
Amawi, Haneen
Ashby, Charles R.
Khare, Vishwa M.
Jones, Veronica
Hari Narayana Moorthy, N.S.
Trivedi, Piyush
Tiwari, Amit K.
author_facet Karthikeyan, Chandrabose
Amawi, Haneen
Ashby, Charles R.
Khare, Vishwa M.
Jones, Veronica
Hari Narayana Moorthy, N.S.
Trivedi, Piyush
Tiwari, Amit K.
author_sort Karthikeyan, Chandrabose
collection PubMed
description A novel series of 3-((2-chloroquinolin-3-yl)methylene)indolin-2-ones were synthesized, using the ‘molecular hybridization approach’ and evaluated for anticancer efficacy. Eleven 3-((2-chloroquinolin-3-yl)methylene)indolin-2-ones (LM01 to LM11) were synthesized and evaluated for in vitro cytotoxic efficacy in cancer (ovarian, prostate and colon) and two non-cancerous cell lines. Among the 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives, LM08, with a 6-Cl substitution in the 3-quinolinyl moiety, had selective and potent cytotoxic efficacy in the ovarian cancer cell line A2780. Further mechanistic investigations indicated that LM08 significantly inhibited the clonogenic survival of A2780 cancer cells, which was mediated by inducing apoptosis.
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spelling pubmed-65226562019-05-24 Novel 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives produce anticancer efficacy in ovarian cancer in vitro Karthikeyan, Chandrabose Amawi, Haneen Ashby, Charles R. Khare, Vishwa M. Jones, Veronica Hari Narayana Moorthy, N.S. Trivedi, Piyush Tiwari, Amit K. Heliyon Article A novel series of 3-((2-chloroquinolin-3-yl)methylene)indolin-2-ones were synthesized, using the ‘molecular hybridization approach’ and evaluated for anticancer efficacy. Eleven 3-((2-chloroquinolin-3-yl)methylene)indolin-2-ones (LM01 to LM11) were synthesized and evaluated for in vitro cytotoxic efficacy in cancer (ovarian, prostate and colon) and two non-cancerous cell lines. Among the 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives, LM08, with a 6-Cl substitution in the 3-quinolinyl moiety, had selective and potent cytotoxic efficacy in the ovarian cancer cell line A2780. Further mechanistic investigations indicated that LM08 significantly inhibited the clonogenic survival of A2780 cancer cells, which was mediated by inducing apoptosis. Elsevier 2019-05-14 /pmc/articles/PMC6522656/ /pubmed/31193218 http://dx.doi.org/10.1016/j.heliyon.2019.e01603 Text en © 2019 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Karthikeyan, Chandrabose
Amawi, Haneen
Ashby, Charles R.
Khare, Vishwa M.
Jones, Veronica
Hari Narayana Moorthy, N.S.
Trivedi, Piyush
Tiwari, Amit K.
Novel 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives produce anticancer efficacy in ovarian cancer in vitro
title Novel 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives produce anticancer efficacy in ovarian cancer in vitro
title_full Novel 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives produce anticancer efficacy in ovarian cancer in vitro
title_fullStr Novel 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives produce anticancer efficacy in ovarian cancer in vitro
title_full_unstemmed Novel 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives produce anticancer efficacy in ovarian cancer in vitro
title_short Novel 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives produce anticancer efficacy in ovarian cancer in vitro
title_sort novel 3-((2-chloroquinolin-3-yl)methylene)indolin-2-one derivatives produce anticancer efficacy in ovarian cancer in vitro
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522656/
https://www.ncbi.nlm.nih.gov/pubmed/31193218
http://dx.doi.org/10.1016/j.heliyon.2019.e01603
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