LncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis

Long non-coding RNAs (lncRNA) CASC2 is a key player in cancer biology. Our new findings showed that both lncRNA CASC2 and IL-17 were up-regulated in plasma of osteoarthritis patients. Plasma levels of lncRNA CASC2 and IL-17 were significantly and positive correlated only in osteoarthritis patients....

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Autores principales: Huang, Tao, Wang, Jian, Zhou, Yuan, Zhao, Yi, Hang, Donghua, Cao, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522707/
https://www.ncbi.nlm.nih.gov/pubmed/31015370
http://dx.doi.org/10.1042/BSR20182454
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author Huang, Tao
Wang, Jian
Zhou, Yuan
Zhao, Yi
Hang, Donghua
Cao, Yun
author_facet Huang, Tao
Wang, Jian
Zhou, Yuan
Zhao, Yi
Hang, Donghua
Cao, Yun
author_sort Huang, Tao
collection PubMed
description Long non-coding RNAs (lncRNA) CASC2 is a key player in cancer biology. Our new findings showed that both lncRNA CASC2 and IL-17 were up-regulated in plasma of osteoarthritis patients. Plasma levels of lncRNA CASC2 and IL-17 were significantly and positive correlated only in osteoarthritis patients. Overexpression of lncRNA CASC2 led to up-regulated expression of IL-17 in cells of human chondrocyte cell line CHON-001 (ATCC(®) CRL-2846™). In addition, overexpression of lncRNA CASC2 inhibited the proliferation, and promoted the apoptosis of chondrocyte. Therefore, lncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis.
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spelling pubmed-65227072019-05-28 LncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis Huang, Tao Wang, Jian Zhou, Yuan Zhao, Yi Hang, Donghua Cao, Yun Biosci Rep Research Articles Long non-coding RNAs (lncRNA) CASC2 is a key player in cancer biology. Our new findings showed that both lncRNA CASC2 and IL-17 were up-regulated in plasma of osteoarthritis patients. Plasma levels of lncRNA CASC2 and IL-17 were significantly and positive correlated only in osteoarthritis patients. Overexpression of lncRNA CASC2 led to up-regulated expression of IL-17 in cells of human chondrocyte cell line CHON-001 (ATCC(®) CRL-2846™). In addition, overexpression of lncRNA CASC2 inhibited the proliferation, and promoted the apoptosis of chondrocyte. Therefore, lncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis. Portland Press Ltd. 2019-05-14 /pmc/articles/PMC6522707/ /pubmed/31015370 http://dx.doi.org/10.1042/BSR20182454 Text en © 2019 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Articles
Huang, Tao
Wang, Jian
Zhou, Yuan
Zhao, Yi
Hang, Donghua
Cao, Yun
LncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis
title LncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis
title_full LncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis
title_fullStr LncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis
title_full_unstemmed LncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis
title_short LncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis
title_sort lncrna casc2 is up-regulated in osteoarthritis and participates in the regulation of il-17 expression and chondrocyte proliferation and apoptosis
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522707/
https://www.ncbi.nlm.nih.gov/pubmed/31015370
http://dx.doi.org/10.1042/BSR20182454
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