Letter to the Editor: Comments on “Association between the ICAM-1 gene polymorphism and coronary heart disease risk: a meta-analysis”

Yin et al. (Bioscience Reports (2019) 39, BSR20180923) recently published a meta-analysis about the association between the K469E (rs5498) polymorphism and risk of coronary heart disease (CHD). Authors included 14 studies based on their inclusion criteria. They indicated that only studies which their genotyping data were in Hardy–Weinberg equilibrium (HWE) were included in their meta-analysis. They also tested HWE for these studies and found all the control groups in HWE. As their main finding, they concluded that ‘K469E polymorphism is associated with CHD risk and the K allele is a more significant risk factor for developing CHD amongst Chinese and Caucasians populations’. However, there seems to be presenting some mistakes in HWE test which strongly affects included studies and the final conclusion. Here we aim to comment on the issue.