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Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis
BACKGROUND: The coexistence of sarcopenia and obesity is referred to as sarcopenic obesity (SO) and it has been hypothesized that the two components of SO may synergistically increase their negative effects. However, many uncertainties still surround this condition especially with regard to its pote...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522758/ https://www.ncbi.nlm.nih.gov/pubmed/31139318 http://dx.doi.org/10.4239/wjd.v10.i5.311 |
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author | Khadra, Dima Itani, Leila Tannir, Hana Kreidieh, Dima El Masri, Dana El Ghoch, Marwan |
author_facet | Khadra, Dima Itani, Leila Tannir, Hana Kreidieh, Dima El Masri, Dana El Ghoch, Marwan |
author_sort | Khadra, Dima |
collection | PubMed |
description | BACKGROUND: The coexistence of sarcopenia and obesity is referred to as sarcopenic obesity (SO) and it has been hypothesized that the two components of SO may synergistically increase their negative effects. However, many uncertainties still surround this condition especially with regard to its potential negative effects on health outcomes. AIM: To conduct a systematic review to determine the prevalence of sarcopenia among adults with overweight and obesity and to investigate whether SO was associated with a higher risk of type 2 diabetes (T2D). METHODS: This study was conducted in adherence with the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. Literature searches, study selection, methodology development and quality appraisal were performed independently by two authors and the data were collated by means of meta-analysis and narrative synthesis. RESULTS: Of the 606 articles retrieved, 11 studies that comprised a total of 60118 adults with overweight and obesity of both genders met the inclusion criteria and were reviewed, revealing two main findings. First, the overall prevalence of sarcopenia is 43% in females and 42% in males who are with overweight and obesity. Secondly, the presence of SO increases the risk of T2D by 38% with respect to those without SO (OR = 1.38, 95%CI: 1.27-1.50). CONCLUSION: A high prevalence of sarcopenia has been found among adults with overweight and obesity regardless of their gender and this condition seems to be associated with a higher risk of T2D. Clinician should be aware of this scenario in their clinical practice for the better management of both obesity and T2D. |
format | Online Article Text |
id | pubmed-6522758 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-65227582019-05-28 Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis Khadra, Dima Itani, Leila Tannir, Hana Kreidieh, Dima El Masri, Dana El Ghoch, Marwan World J Diabetes Meta-Analysis BACKGROUND: The coexistence of sarcopenia and obesity is referred to as sarcopenic obesity (SO) and it has been hypothesized that the two components of SO may synergistically increase their negative effects. However, many uncertainties still surround this condition especially with regard to its potential negative effects on health outcomes. AIM: To conduct a systematic review to determine the prevalence of sarcopenia among adults with overweight and obesity and to investigate whether SO was associated with a higher risk of type 2 diabetes (T2D). METHODS: This study was conducted in adherence with the Preferred Reporting Items for Systematic Review and Meta-Analyses guidelines. Literature searches, study selection, methodology development and quality appraisal were performed independently by two authors and the data were collated by means of meta-analysis and narrative synthesis. RESULTS: Of the 606 articles retrieved, 11 studies that comprised a total of 60118 adults with overweight and obesity of both genders met the inclusion criteria and were reviewed, revealing two main findings. First, the overall prevalence of sarcopenia is 43% in females and 42% in males who are with overweight and obesity. Secondly, the presence of SO increases the risk of T2D by 38% with respect to those without SO (OR = 1.38, 95%CI: 1.27-1.50). CONCLUSION: A high prevalence of sarcopenia has been found among adults with overweight and obesity regardless of their gender and this condition seems to be associated with a higher risk of T2D. Clinician should be aware of this scenario in their clinical practice for the better management of both obesity and T2D. Baishideng Publishing Group Inc 2019-05-15 2019-05-15 /pmc/articles/PMC6522758/ /pubmed/31139318 http://dx.doi.org/10.4239/wjd.v10.i5.311 Text en ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Meta-Analysis Khadra, Dima Itani, Leila Tannir, Hana Kreidieh, Dima El Masri, Dana El Ghoch, Marwan Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis |
title | Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis |
title_full | Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis |
title_fullStr | Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis |
title_full_unstemmed | Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis |
title_short | Association between sarcopenic obesity and higher risk of type 2 diabetes in adults: A systematic review and meta-analysis |
title_sort | association between sarcopenic obesity and higher risk of type 2 diabetes in adults: a systematic review and meta-analysis |
topic | Meta-Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522758/ https://www.ncbi.nlm.nih.gov/pubmed/31139318 http://dx.doi.org/10.4239/wjd.v10.i5.311 |
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