Cargando…

Mapping the metabolism of five amino acids in bloodstream form Trypanosoma brucei using U-(13)C-labelled substrates and LC–MS

The metabolism of the parasite Trypanosoma brucei has been the focus of numerous studies since the 1940s. Recently it was shown, using metabolomics coupled with heavy-atom isotope labelled glucose, that the metabolism of the bloodstream form parasite is more complex than previously thought. The pres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Johnston, Katharina, Kim, Dong-Hyun, Kerkhoven, Eduard J., Burchmore, Richard, Barrett, Michael P., Achcar, Fiona
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522824/ https://www.ncbi.nlm.nih.gov/pubmed/31028136 http://dx.doi.org/10.1042/BSR20181601

Ejemplares similares

Dynamic Modelling under Uncertainty: The Case of Trypanosoma brucei Energy Metabolism
por: Achcar, Fiona, et al.
Publicado: (2012)

Handling Uncertainty in Dynamic Models: The Pentose Phosphate Pathway in Trypanosoma brucei
por: Kerkhoven, Eduard J., et al.
Publicado: (2013)

Probing the Metabolic Network in Bloodstream-Form Trypanosoma brucei Using Untargeted Metabolomics with Stable Isotope Labelled Glucose
por: Creek, Darren J., et al.
Publicado: (2015)

Gluconeogenesis using glycerol as a substrate in bloodstream-form Trypanosoma brucei
por: Kovářová, Julie, et al.
Publicado: (2018)

Crystal Structure of an Arginase-like Protein from Trypanosoma brucei That Evolved without a Binuclear Manganese Cluster
por: Hai, Yang, et al.
Publicado: (2014)

Transcriptional differentiation of Trypanosoma brucei during in vitro acquisition of resistance to acoziborole
por: Steketee, Pieter C., et al.
Publicado: (2021)

Mitochondrion of the Trypanosoma brucei long slender bloodstream form is capable of ATP production by substrate-level phosphorylation
por: Taleva, Gergana, et al.
Publicado: (2023)

Halogenated tryptophan derivatives disrupt essential transamination mechanisms in bloodstream form Trypanosoma brucei
por: Cockram, Peter E., et al.
Publicado: (2020)

Centromere-associated topoisomerase activity in bloodstream form Trypanosoma brucei
por: Obado, Samson O., et al.
Publicado: (2011)

Pyrimidine Biosynthesis Is Not an Essential Function for Trypanosoma brucei Bloodstream Forms
por: Ali, Juma A. M., et al.
Publicado: (2013)

Bloodstream form pre-adaptation to the tsetse fly in Trypanosoma brucei
por: Rico, Eva, et al.
Publicado: (2013)

In vitro growth inhibition of bloodstream forms of Trypanosoma brucei and Trypanosoma congolense by iron chelators
por: Merschjohann, Karin, et al.
Publicado: (2006)

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei
por: Steketee, Pieter C., et al.
Publicado: (2018)

Isolation and characterization of kinetoplast DNA from bloodstream form of Trypanosoma brucei
por: Fairlamb, A. H., et al.
Publicado: (1978)

KREX2 Is Not Essential for Either Procyclic or Bloodstream Form Trypanosoma brucei
por: Carnes, Jason, et al.
Publicado: (2012)

The ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei
por: Gibellini, Federica, et al.
Publicado: (2009)

Cell density-dependent ectopic expression in bloodstream form Trypanosoma brucei
por: Ali, Moazzam, et al.
Publicado: (2013)

Mitochondrial growth during the cell cycle of Trypanosoma brucei bloodstream forms
por: Jakob, Martin, et al.
Publicado: (2016)

Analysis of the Trypanosoma brucei EATRO 164 Bloodstream Guide RNA Transcriptome
por: Kirby, Laura E., et al.
Publicado: (2016)

Novel aspects of iron homeostasis in pathogenic bloodstream form Trypanosoma brucei
por: Gilabert Carbajo, Carla, et al.
Publicado: (2021)

LC–MS-based absolute metabolite quantification: application to metabolic flux measurement in trypanosomes
por: Kim, Dong-Hyun, et al.
Publicado: (2015)

Untargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei
por: Vincent, Isabel M., et al.
Publicado: (2012)

In vitro culture of freshly isolated Trypanosoma brucei brucei bloodstream forms results in gene copy-number changes
por: Mulindwa, Julius, et al.
Publicado: (2021)

Casein kinase 1 isoform 2 is essential for bloodstream form Trypanosoma brucei()
por: Urbaniak, Michael D.
Publicado: (2009)

The Phosphoproteome of Bloodstream Form Trypanosoma brucei, Causative Agent of African Sleeping Sickness
por: Nett, Isabelle R. E., et al.
Publicado: (2009)

Channel-Forming Activities in the Glycosomal Fraction from the Bloodstream Form of Trypanosoma brucei
por: Gualdron-López, Melisa, et al.
Publicado: (2012)

Comparative SILAC Proteomic Analysis of Trypanosoma brucei Bloodstream and Procyclic Lifecycle Stages
por: Urbaniak, Michael D., et al.
Publicado: (2012)

Cytokinesis in Bloodstream Stage Trypanosoma brucei Requires a Family of Katanins and Spastin
por: Benz, Corinna, et al.
Publicado: (2012)

The essential roles of cytidine diphosphate‐diacylglycerol synthase in bloodstream form Trypanosoma brucei
por: Lilley, Alison C., et al.
Publicado: (2014)

NADH dehydrogenase of Trypanosoma brucei is important for efficient acetate production in bloodstream forms
por: Surve, Sachin V., et al.
Publicado: (2017)

A paradigm shift: The mitoproteomes of procyclic and bloodstream Trypanosoma brucei are comparably complex
por: Zíková, Alena, et al.
Publicado: (2017)

Vacuolar ATPase depletion contributes to dysregulation of endocytosis in bloodstream forms of Trypanosoma brucei
por: Xu, Zhi-Shen, et al.
Publicado: (2020)

Proteome turnover in the bloodstream and procyclic forms of Trypanosoma brucei measured by quantitative proteomics
por: Tinti, Michele, et al.
Publicado: (2019)

Nucleotide sugar biosynthesis occurs in the glycosomes of procyclic and bloodstream form Trypanosoma brucei
por: Sampaio Guther, Maria Lucia, et al.
Publicado: (2021)

FAZ assembly in bloodstream form Trypanosoma brucei requires kinesin KIN-E
por: Albisetti, Anna C., et al.
Publicado: (2023)

Cysteine eliminates the feeder cell requirement for cultivation of Trypanosoma brucei bloodstream forms in vitro
Publicado: (1985)

Correction: Cytokinesis in Bloodstream Stage Trypanosoma brucei Requires a Family of Katanins and Spastin
por: Benz, Corinna, et al.
Publicado: (2012)

The Cytological Events and Molecular Control of Life Cycle Development of Trypanosoma brucei in the Mammalian Bloodstream
por: Silvester, Eleanor, et al.
Publicado: (2017)

Alkaloids Induce Programmed Cell Death in Bloodstream Forms of Trypanosomes (Trypanosoma b. brucei)
por: Rosenkranz, Vera, et al.
Publicado: (2008)

Several different sequences are implicated in bloodstream-form-specific gene expression in Trypanosoma brucei
por: Bishola Tshitenge, Tania, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_eos24nrl7bifkb6l19acnrq3pf