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Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach

7-methoxytacrine-4-pyridinealdoxime (7-MEOTA-4-PA, named hybrid 5C) is a compound formerly synthesized and evaluated in vitro, together with 4-pyridine aldoxime (4-PA) and commercial reactivators of acetylcholinesterase (AChE). This compound was designed with the purpose of being a prophylactic reac...

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Detalles Bibliográficos
Autores principales:	da Silva, Jorge Alberto Valle, Nepovimova, Eugenie, Ramalho, Teodorico Castro, Kuca, Kamil, Celmar Costa França, Tanos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522925/ https://www.ncbi.nlm.nih.gov/pubmed/31074292 http://dx.doi.org/10.1080/14756366.2019.1609953

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