Cargando…

Neural Stem Cells of Parkinson's Disease Patients Exhibit Aberrant Mitochondrial Morphology and Functionality

Emerging evidence suggests that Parkinson's disease (PD), besides being an age-associated disorder, might also have a neurodevelopment component. Disruption of mitochondrial homeostasis has been highlighted as a crucial cofactor in its etiology. Here, we show that PD patient-specific human neur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Walter, Jonas, Bolognin, Silvia, Antony, Paul M.A., Nickels, Sarah L., Poovathingal, Suresh K., Salamanca, Luis, Magni, Stefano, Perfeito, Rita, Hoel, Fredrik, Qing, Xiaobing, Jarazo, Javier, Arias-Fuenzalida, Jonathan, Ignac, Tomasz, Monzel, Anna S., Gonzalez-Cano, Laura, Pereira de Almeida, Luis, Skupin, Alexander, Tronstad, Karl J., Schwamborn, Jens C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6522948/ https://www.ncbi.nlm.nih.gov/pubmed/30982740 http://dx.doi.org/10.1016/j.stemcr.2019.03.004

Ejemplares similares

FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling
por: Arias-Fuenzalida, Jonathan, et al.
Publicado: (2017)

3D Cultures of Parkinson's Disease‐Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing
por: Bolognin, Silvia, et al.
Publicado: (2018)

Guidelines for Fluorescent Guided Biallelic HDR Targeting Selection With PiggyBac System Removal for Gene Editing
por: Jarazo, Javier, et al.
Publicado: (2019)

Automated high-throughput high-content autophagy and mitophagy analysis platform
por: Arias-Fuenzalida, Jonathan, et al.
Publicado: (2019)

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells
por: Monzel, Anna S., et al.
Publicado: (2017)

Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids
por: Smits, Lisa M., et al.
Publicado: (2020)

Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2‐Hydroxypropyl‐β‐Cyclodextrin Treatment
por: Jarazo, Javier, et al.
Publicado: (2021)

Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis
por: Gomez-Giro, Gemma, et al.
Publicado: (2019)

Rapid and robust generation of long-term self-renewing human neural stem cells with the ability to generate mature astroglia
por: Palm, Thomas, et al.
Publicado: (2015)

Discovering Pair-Wise Genetic Interactions: An Information Theory-Based Approach
por: Ignac, Tomasz M., et al.
Publicado: (2014)

A robust protocol for the generation of human midbrain organoids
por: Zagare, Alise, et al.
Publicado: (2021)

Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-p.Gly2019Ser-associated gene expression
por: Zagare, Alise, et al.
Publicado: (2022)

Quality Control Strategy for CRISPR-Cas9-Based Gene Editing Complicated by a Pseudogene
por: Hanss, Zoé, et al.
Publicado: (2020)

Modeling Parkinson’s disease in midbrain-like organoids
por: Smits, Lisa M., et al.
Publicado: (2019)

Is serine racemase (SRR) a second hit target for LRRK2-G2019S induced Parkinson’s disease?
por: Nickels, Sarah Louise, et al.
Publicado: (2020)

Bone Tissue and the Nervous System: What Do They Have in Common?
por: Minoia, Arianna, et al.
Publicado: (2022)

MIC‐MAC: An automated pipeline for high‐throughput characterization and classification of three‐dimensional microglia morphologies in mouse and human postmortem brain samples
por: Salamanca, Luis, et al.
Publicado: (2019)

Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening
por: Boussaad, Ibrahim, et al.
Publicado: (2021)

Do patients with schizophrenia exhibit aberrant salience?
por: Roiser, J. P., et al.
Publicado: (2009)

Impaired mitochondrial–endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson’s disease
por: Berenguer-Escuder, Clara, et al.
Publicado: (2020)

Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient‐Derived Neurons
por: Hanss, Zoé, et al.
Publicado: (2020)

PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons
por: Brown, Sarah J., et al.
Publicado: (2021)

Data-driven dynamical model indicates that the heat shock response in Chlamydomonas reinhardtii is tailored to handle natural temperature variation
por: Magni, Stefano, et al.
Publicado: (2018)

Axl‐inhibitor bemcentinib alleviates mitochondrial dysfunction in the unilateral ureter obstruction murine model
por: Hoel, August, et al.
Publicado: (2021)

Global parameter estimation methods for stochastic biochemical systems
por: Poovathingal, Suresh Kumar, et al.
Publicado: (2010)

Omics data integration suggests a potential idiopathic Parkinson’s disease signature
por: Zagare, Alise, et al.
Publicado: (2023)

Structural Plasticity of Dopaminergic Neurons Requires the Activation of the D3R-nAChR Heteromer and the PI3K-ERK1/2/Akt-Induced Expression of c-Fos and p70S6K Signaling Pathway
por: Mutti, Veronica, et al.
Publicado: (2022)

Pancreatic mitochondrial complex I exhibits aberrant hyperactivity in diabetes()
por: Wu, Jinzi, et al.
Publicado: (2017)

Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality
por: Sabate‐Soler, Sonia, et al.
Publicado: (2022)

Peptide-mediated delivery of donor mitochondria improves mitochondrial function and cell viability in human cybrid cells with the MELAS A3243G mutation
por: Chang, Jui-Chih, et al.
Publicado: (2017)

Single‐cell transcriptomics reveals distinct inflammation‐induced microglia signatures
por: Sousa, Carole, et al.
Publicado: (2018)

Treating Parkinson’s Disease with Human Bone Marrow Mesenchymal Stem Cell Secretome: A Translational Investigation Using Human Brain Organoids and Different Routes of In Vivo Administration
por: Mendes-Pinheiro, Bárbara, et al.
Publicado: (2023)

Aberration correction in 2D echocardiography
por: Måsøy, Svein-Erik, et al.
Publicado: (2023)

Mice With Decreased Number of Interneurons Exhibit Aberrant Spontaneous and Oscillatory Activity in the Cortex
por: Kalemaki, Katerina, et al.
Publicado: (2018)

Gene regulatory networks exhibit several kinds of memory: quantification of memory in biological and random transcriptional networks
por: Biswas, Surama, et al.
Publicado: (2021)

Stochastic Drift in Mitochondrial DNA Point Mutations: A Novel Perspective Ex Silico
por: Poovathingal, Suresh Kumar, et al.
Publicado: (2009)

Enteric neurons from Parkinson’s disease patients display ex vivo aberrations in mitochondrial structure
por: Baumuratov, A. S., et al.
Publicado: (2016)

VMP1-deficient Chlamydomonas exhibits severely aberrant cell morphology and disrupted cytokinesis
por: Tenenboim, Hezi, et al.
Publicado: (2014)

An atlas of clinical nuclear medicine
por: Fogelman, Ignac, 1948-
Publicado: (1994)

Microglia phenotypes are associated with subregional patterns of concomitant tau, amyloid-β and α-synuclein pathologies in the hippocampus of patients with Alzheimer’s disease and dementia with Lewy bodies
por: Fixemer, Sonja, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_8o84f2gr6mnn972qv0663vontv