Nucleoid-Associated Protein HU: A Lilliputian in Gene Regulation of Bacterial Virulence

Nucleoid-associated proteins belong to a group of small but abundant proteins in bacterial cells. These transcription regulators are responsible for many important cellular processes and also are involved in pathogenesis of bacteria. The best-known nucleoid-associated proteins, such as HU, FIS, H-NS...

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Autores principales: Stojkova, Pavla, Spidlova, Petra, Stulik, Jiri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523023/
https://www.ncbi.nlm.nih.gov/pubmed/31134164
http://dx.doi.org/10.3389/fcimb.2019.00159
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author Stojkova, Pavla
Spidlova, Petra
Stulik, Jiri
author_facet Stojkova, Pavla
Spidlova, Petra
Stulik, Jiri
author_sort Stojkova, Pavla
collection PubMed
description Nucleoid-associated proteins belong to a group of small but abundant proteins in bacterial cells. These transcription regulators are responsible for many important cellular processes and also are involved in pathogenesis of bacteria. The best-known nucleoid-associated proteins, such as HU, FIS, H-NS, and IHF, are often discussed. The most important findings in research concerning HU protein are described in this mini review. Its roles in DNA compaction, shape modulation, and negative supercoiling induction have been studied intensively. HU protein regulates bacteria survival, growth, SOS response, virulence genes expression, cell division, and many other cell processes. Elucidating the mechanism of HU protein action has been the subject of many research projects. This mini review provides a comprehensive overview of the HU protein.
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spelling pubmed-65230232019-05-27 Nucleoid-Associated Protein HU: A Lilliputian in Gene Regulation of Bacterial Virulence Stojkova, Pavla Spidlova, Petra Stulik, Jiri Front Cell Infect Microbiol Cellular and Infection Microbiology Nucleoid-associated proteins belong to a group of small but abundant proteins in bacterial cells. These transcription regulators are responsible for many important cellular processes and also are involved in pathogenesis of bacteria. The best-known nucleoid-associated proteins, such as HU, FIS, H-NS, and IHF, are often discussed. The most important findings in research concerning HU protein are described in this mini review. Its roles in DNA compaction, shape modulation, and negative supercoiling induction have been studied intensively. HU protein regulates bacteria survival, growth, SOS response, virulence genes expression, cell division, and many other cell processes. Elucidating the mechanism of HU protein action has been the subject of many research projects. This mini review provides a comprehensive overview of the HU protein. Frontiers Media S.A. 2019-05-10 /pmc/articles/PMC6523023/ /pubmed/31134164 http://dx.doi.org/10.3389/fcimb.2019.00159 Text en Copyright © 2019 Stojkova, Spidlova and Stulik. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Stojkova, Pavla
Spidlova, Petra
Stulik, Jiri
Nucleoid-Associated Protein HU: A Lilliputian in Gene Regulation of Bacterial Virulence
title Nucleoid-Associated Protein HU: A Lilliputian in Gene Regulation of Bacterial Virulence
title_full Nucleoid-Associated Protein HU: A Lilliputian in Gene Regulation of Bacterial Virulence
title_fullStr Nucleoid-Associated Protein HU: A Lilliputian in Gene Regulation of Bacterial Virulence
title_full_unstemmed Nucleoid-Associated Protein HU: A Lilliputian in Gene Regulation of Bacterial Virulence
title_short Nucleoid-Associated Protein HU: A Lilliputian in Gene Regulation of Bacterial Virulence
title_sort nucleoid-associated protein hu: a lilliputian in gene regulation of bacterial virulence
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523023/
https://www.ncbi.nlm.nih.gov/pubmed/31134164
http://dx.doi.org/10.3389/fcimb.2019.00159
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