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Insights into the Link between the Organization of DNA Replication and the Mutational Landscape
The generation of a complete and accurate copy of the genetic material during each cell cycle is integral to cell growth and proliferation. However, genetic diversity is essential for adaptation and evolution, and the process of DNA replication is a fundamental source of mutations. Genome alteration...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523204/ https://www.ncbi.nlm.nih.gov/pubmed/30934791 http://dx.doi.org/10.3390/genes10040252 |
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author | Gaboriaud, Julia Wu, Pei-Yun Jenny |
author_facet | Gaboriaud, Julia Wu, Pei-Yun Jenny |
author_sort | Gaboriaud, Julia |
collection | PubMed |
description | The generation of a complete and accurate copy of the genetic material during each cell cycle is integral to cell growth and proliferation. However, genetic diversity is essential for adaptation and evolution, and the process of DNA replication is a fundamental source of mutations. Genome alterations do not accumulate randomly, with variations in the types and frequencies of mutations that arise in different genomic regions. Intriguingly, recent studies revealed a striking link between the mutational landscape of a genome and the spatial and temporal organization of DNA replication, referred to as the replication program. In our review, we discuss how this program may contribute to shaping the profile and spectrum of genetic alterations, with implications for genome dynamics and organismal evolution in natural and pathological contexts. |
format | Online Article Text |
id | pubmed-6523204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65232042019-06-03 Insights into the Link between the Organization of DNA Replication and the Mutational Landscape Gaboriaud, Julia Wu, Pei-Yun Jenny Genes (Basel) Review The generation of a complete and accurate copy of the genetic material during each cell cycle is integral to cell growth and proliferation. However, genetic diversity is essential for adaptation and evolution, and the process of DNA replication is a fundamental source of mutations. Genome alterations do not accumulate randomly, with variations in the types and frequencies of mutations that arise in different genomic regions. Intriguingly, recent studies revealed a striking link between the mutational landscape of a genome and the spatial and temporal organization of DNA replication, referred to as the replication program. In our review, we discuss how this program may contribute to shaping the profile and spectrum of genetic alterations, with implications for genome dynamics and organismal evolution in natural and pathological contexts. MDPI 2019-03-27 /pmc/articles/PMC6523204/ /pubmed/30934791 http://dx.doi.org/10.3390/genes10040252 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Gaboriaud, Julia Wu, Pei-Yun Jenny Insights into the Link between the Organization of DNA Replication and the Mutational Landscape |
title | Insights into the Link between the Organization of DNA Replication and the Mutational Landscape |
title_full | Insights into the Link between the Organization of DNA Replication and the Mutational Landscape |
title_fullStr | Insights into the Link between the Organization of DNA Replication and the Mutational Landscape |
title_full_unstemmed | Insights into the Link between the Organization of DNA Replication and the Mutational Landscape |
title_short | Insights into the Link between the Organization of DNA Replication and the Mutational Landscape |
title_sort | insights into the link between the organization of dna replication and the mutational landscape |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523204/ https://www.ncbi.nlm.nih.gov/pubmed/30934791 http://dx.doi.org/10.3390/genes10040252 |
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