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Co-Delivery of M2e Virus-Like Particles with Influenza Split Vaccine to the Skin Using Microneedles Enhances the Efficacy of Cross Protection
It is a high priority to develop a simple and effective delivery method for a cross-protective influenza vaccine. We investigated skin immunization by microneedle (MN) patch with human influenza split vaccine and virus-like particles containing heterologous M2 extracellular (M2e) domains (M2e5x viru...
Autores principales: | Kim, Min-Chul, Kim, Ki-Hye, Lee, Jeong Woo, Lee, Yu-Na, Choi, Hyo-Jick, Jung, Yu-Jin, Kim, Yu-Jin, Compans, Richard W., Prausnitz, Mark R., Kang, Sang-Moo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523215/ https://www.ncbi.nlm.nih.gov/pubmed/31003421 http://dx.doi.org/10.3390/pharmaceutics11040188 |
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