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Impact of treatment planning using a structure block function on the target and organ doses related to patient movement in cervical esophageal cancer: A phantom study

Helical tomotherapy (HT) can restrict beamlets passing through the virtual contour on computed tomography (CT) image in dose optimization, reducing the dose to organs at risk (OARs). Beamlet restriction limits the incident beamlet angles; thus, the proper planning target volume (PTV) margin may diff...

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Autores principales: Shimizu, Hidetoshi, Sasaki, Koji, Ito, Makoto, Aoyama, Takahiro, Tachibana, Hiroyuki, Tomita, Natsuo, Makita, Chiyoko, Tanaka, Hiroshi, Koide, Yutaro, Iwata, Tohru, Kodaira, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523256/
https://www.ncbi.nlm.nih.gov/pubmed/30997729
http://dx.doi.org/10.1002/acm2.12582
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author Shimizu, Hidetoshi
Sasaki, Koji
Ito, Makoto
Aoyama, Takahiro
Tachibana, Hiroyuki
Tomita, Natsuo
Makita, Chiyoko
Tanaka, Hiroshi
Koide, Yutaro
Iwata, Tohru
Kodaira, Takeshi
author_facet Shimizu, Hidetoshi
Sasaki, Koji
Ito, Makoto
Aoyama, Takahiro
Tachibana, Hiroyuki
Tomita, Natsuo
Makita, Chiyoko
Tanaka, Hiroshi
Koide, Yutaro
Iwata, Tohru
Kodaira, Takeshi
author_sort Shimizu, Hidetoshi
collection PubMed
description Helical tomotherapy (HT) can restrict beamlets passing through the virtual contour on computed tomography (CT) image in dose optimization, reducing the dose to organs at risk (OARs). Beamlet restriction limits the incident beamlet angles; thus, the proper planning target volume (PTV) margin may differ from that of the standard treatment plan without beamlet restriction, depending on the patient's movement during dose delivery. Dose distribution changes resulting from patient movement have not been described for treatment plans with beamlet restriction. This study quantified changes in dose distribution to the target and OARs when beamlet restriction is applied to cervical esophageal cancer treatment plan using HT by systematically shifting a phantom. Treatment plans for cervical esophageal cancers with and without beamlet restriction modes [directional block (DB) and nonblock (NB), respectively] were designed for CT images of the RANDO phantom. The PTV margin for the DB mode was set to be the same as that for the NB mode (5 mm). The CT image was intentionally shifted by ±1, ±2, and ±3 voxels in the left–right, anterior–posterior, and superior–inferior directions, and the dose distribution was recalculated for each position using the fluence for the NB or DB mode. When the phantom shift was within the same PTV margin as the NB mode, changes in doses to the targets, lungs, heart, and spinal cord in the DB mode were small as those in the NB mode. In conclusion, the virtual contour shape used in this study would provide safe delivery even with patient movement within the same PTV margin as for the NB mode.
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spelling pubmed-65232562019-05-24 Impact of treatment planning using a structure block function on the target and organ doses related to patient movement in cervical esophageal cancer: A phantom study Shimizu, Hidetoshi Sasaki, Koji Ito, Makoto Aoyama, Takahiro Tachibana, Hiroyuki Tomita, Natsuo Makita, Chiyoko Tanaka, Hiroshi Koide, Yutaro Iwata, Tohru Kodaira, Takeshi J Appl Clin Med Phys Radiation Oncology Physics Helical tomotherapy (HT) can restrict beamlets passing through the virtual contour on computed tomography (CT) image in dose optimization, reducing the dose to organs at risk (OARs). Beamlet restriction limits the incident beamlet angles; thus, the proper planning target volume (PTV) margin may differ from that of the standard treatment plan without beamlet restriction, depending on the patient's movement during dose delivery. Dose distribution changes resulting from patient movement have not been described for treatment plans with beamlet restriction. This study quantified changes in dose distribution to the target and OARs when beamlet restriction is applied to cervical esophageal cancer treatment plan using HT by systematically shifting a phantom. Treatment plans for cervical esophageal cancers with and without beamlet restriction modes [directional block (DB) and nonblock (NB), respectively] were designed for CT images of the RANDO phantom. The PTV margin for the DB mode was set to be the same as that for the NB mode (5 mm). The CT image was intentionally shifted by ±1, ±2, and ±3 voxels in the left–right, anterior–posterior, and superior–inferior directions, and the dose distribution was recalculated for each position using the fluence for the NB or DB mode. When the phantom shift was within the same PTV margin as the NB mode, changes in doses to the targets, lungs, heart, and spinal cord in the DB mode were small as those in the NB mode. In conclusion, the virtual contour shape used in this study would provide safe delivery even with patient movement within the same PTV margin as for the NB mode. John Wiley and Sons Inc. 2019-04-17 /pmc/articles/PMC6523256/ /pubmed/30997729 http://dx.doi.org/10.1002/acm2.12582 Text en © 2019 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals, Inc. on behalf of American Association of Physicists in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Shimizu, Hidetoshi
Sasaki, Koji
Ito, Makoto
Aoyama, Takahiro
Tachibana, Hiroyuki
Tomita, Natsuo
Makita, Chiyoko
Tanaka, Hiroshi
Koide, Yutaro
Iwata, Tohru
Kodaira, Takeshi
Impact of treatment planning using a structure block function on the target and organ doses related to patient movement in cervical esophageal cancer: A phantom study
title Impact of treatment planning using a structure block function on the target and organ doses related to patient movement in cervical esophageal cancer: A phantom study
title_full Impact of treatment planning using a structure block function on the target and organ doses related to patient movement in cervical esophageal cancer: A phantom study
title_fullStr Impact of treatment planning using a structure block function on the target and organ doses related to patient movement in cervical esophageal cancer: A phantom study
title_full_unstemmed Impact of treatment planning using a structure block function on the target and organ doses related to patient movement in cervical esophageal cancer: A phantom study
title_short Impact of treatment planning using a structure block function on the target and organ doses related to patient movement in cervical esophageal cancer: A phantom study
title_sort impact of treatment planning using a structure block function on the target and organ doses related to patient movement in cervical esophageal cancer: a phantom study
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523256/
https://www.ncbi.nlm.nih.gov/pubmed/30997729
http://dx.doi.org/10.1002/acm2.12582
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