Modulation of the Release of a Non-Interacting Low Solubility Drug from Chitosan Pellets Using Different Pellet Size, Composition and Numerical Optimization

Two size classes of piroxicam (PXC) pellets (mini (380–550 μm) and conventional (700–1200 μm)) were prepared using extrusion/spheronization and medium viscosity chitosan (CHS). Mixture experimental design and numerical optimization were applied to distinguish formulations producing high sphericity p...

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Detalles Bibliográficos
Autores principales: Partheniadis, Ioannis, Gkogkou, Paraskevi, Kantiranis, Nikolaos, Nikolakakis, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523273/
https://www.ncbi.nlm.nih.gov/pubmed/30974869
http://dx.doi.org/10.3390/pharmaceutics11040175

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523273/
https://www.ncbi.nlm.nih.gov/pubmed/30974869
http://dx.doi.org/10.3390/pharmaceutics11040175

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