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Mitochondrial DNA: Distribution, Mutations, and Elimination

Mitochondrion harbors its own DNA (mtDNA), which encodes many critical proteins for the assembly and activity of mitochondrial respiratory complexes. mtDNA is packed by many proteins to form a nucleoid that uniformly distributes within the mitochondrial matrix, which is essential for mitochondrial f...

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Autores principales: Yan, Chaojun, Duanmu, Xiaoying, Zeng, Ling, Liu, Bing, Song, Zhiyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523345/
https://www.ncbi.nlm.nih.gov/pubmed/31027297
http://dx.doi.org/10.3390/cells8040379
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author Yan, Chaojun
Duanmu, Xiaoying
Zeng, Ling
Liu, Bing
Song, Zhiyin
author_facet Yan, Chaojun
Duanmu, Xiaoying
Zeng, Ling
Liu, Bing
Song, Zhiyin
author_sort Yan, Chaojun
collection PubMed
description Mitochondrion harbors its own DNA (mtDNA), which encodes many critical proteins for the assembly and activity of mitochondrial respiratory complexes. mtDNA is packed by many proteins to form a nucleoid that uniformly distributes within the mitochondrial matrix, which is essential for mitochondrial functions. Defects or mutations of mtDNA result in a range of diseases. Damaged mtDNA could be eliminated by mitophagy, and all paternal mtDNA are degraded by endonuclease G or mitophagy during fertilization. In this review, we describe the role and mechanism of mtDNA distribution and elimination. In particular, we focus on the regulation of paternal mtDNA elimination in the process of fertilization.
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spelling pubmed-65233452019-06-03 Mitochondrial DNA: Distribution, Mutations, and Elimination Yan, Chaojun Duanmu, Xiaoying Zeng, Ling Liu, Bing Song, Zhiyin Cells Review Mitochondrion harbors its own DNA (mtDNA), which encodes many critical proteins for the assembly and activity of mitochondrial respiratory complexes. mtDNA is packed by many proteins to form a nucleoid that uniformly distributes within the mitochondrial matrix, which is essential for mitochondrial functions. Defects or mutations of mtDNA result in a range of diseases. Damaged mtDNA could be eliminated by mitophagy, and all paternal mtDNA are degraded by endonuclease G or mitophagy during fertilization. In this review, we describe the role and mechanism of mtDNA distribution and elimination. In particular, we focus on the regulation of paternal mtDNA elimination in the process of fertilization. MDPI 2019-04-25 /pmc/articles/PMC6523345/ /pubmed/31027297 http://dx.doi.org/10.3390/cells8040379 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yan, Chaojun
Duanmu, Xiaoying
Zeng, Ling
Liu, Bing
Song, Zhiyin
Mitochondrial DNA: Distribution, Mutations, and Elimination
title Mitochondrial DNA: Distribution, Mutations, and Elimination
title_full Mitochondrial DNA: Distribution, Mutations, and Elimination
title_fullStr Mitochondrial DNA: Distribution, Mutations, and Elimination
title_full_unstemmed Mitochondrial DNA: Distribution, Mutations, and Elimination
title_short Mitochondrial DNA: Distribution, Mutations, and Elimination
title_sort mitochondrial dna: distribution, mutations, and elimination
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523345/
https://www.ncbi.nlm.nih.gov/pubmed/31027297
http://dx.doi.org/10.3390/cells8040379
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AT duanmuxiaoying mitochondrialdnadistributionmutationsandelimination
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AT songzhiyin mitochondrialdnadistributionmutationsandelimination