Cargando…

TLR1/2 Specific Small‐Molecule Agonist Suppresses Leukemia Cancer Cell Growth by Stimulating Cytotoxic T Lymphocytes

Toll‐like receptor 2 (TLR2) expressed on antigen presenting cells evokes a series of critical cytokines, which favor the development of tumor‐specific cytotoxic T lymphocytes (CTLs). Therefore, TLR2 represents an attractive cancer immunotherapeutic target. Here, a synthetic library of 14 000 compoun...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cen, Xiaohong, Zhu, Gengzhen, Yang, Junjie, Yang, Jianjun, Guo, Jiayin, Jin, Jiabing, Nandakumar, Kutty Selva, Yang, Wei, Yin, Hang, Liu, Shuwen, Cheng, Kui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523386/ https://www.ncbi.nlm.nih.gov/pubmed/31131189 http://dx.doi.org/10.1002/advs.201802042

Ejemplares similares

Small molecule SMU-CX24 targeting toll-like receptor 3 counteracts inflammation: A novel approach to atherosclerosis therapy
por: Cen, Xiaohong, et al.
Publicado: (2022)

Specific activation of the TLR1-TLR2 heterodimer by small-molecule agonists
por: Cheng, Kui, et al.
Publicado: (2015)

Potential treatment methods targeting 2019-nCoV infection
por: Zheng, Lu, et al.
Publicado: (2020)

Targeting IgG in Arthritis: Disease Pathways and Therapeutic Avenues
por: Nandakumar, Kutty Selva
Publicado: (2018)

Vaccines and Vaccine Adjuvants for Infectious Diseases and Autoimmune Diseases
por: Nandakumar, Kutty Selva
Publicado: (2023)

Antibody-induced arthritis: disease mechanisms and genes involved at the effector phase of arthritis
por: Nandakumar, Kutty Selva, et al.
Publicado: (2006)

Editorial: Systemic lupus erythematosus - predisposition factors, pathogenesis, diagnosis, treatment and disease models
por: Nandakumar, Kutty Selva, et al.
Publicado: (2022)

Epicutaneous Application of Mannan Induces Psoriasis-like Inflammation in an Inbred Mouse Strain
por: Wu, Huimei, et al.
Publicado: (2023)

Discovery of novel aporphine alkaloid derivative as potent TLR2 antagonist reversing macrophage polarization and neutrophil infiltration against acute inflammation
por: Yang, Junjie, et al.
Publicado: (2023)

TLR8 agonist VTX-2337 enhances NKG2D-mediated cytotoxicity of NK cells
por: Lu, Hailing, et al.
Publicado: (2013)

The Role of Toll-Like Receptor in Inflammation and Tumor Immunity
por: Cen, Xiaohong, et al.
Publicado: (2018)

Polymer Chemistry Defines Adjuvant Properties and Determines the Immune Response against the Antigen or Vaccine
por: Shakya, Akhilesh Kumar, et al.
Publicado: (2023)

Distinct Costimulatory Molecules Are Required for the Induction of Effector and Memory Cytotoxic T Lymphocytes
por: Liu, Yang, et al.
Publicado: (1997)

GLP-1 Receptor Activation Abrogates β-Cell Dysfunction by PKA Cα-Mediated Degradation of Thioredoxin Interacting Protein
por: He, Shijun, et al.
Publicado: (2019)

Type IX collagen deficiency enhances the binding of cartilage-specific antibodies and arthritis severity
por: Carlsen, Stefan, et al.
Publicado: (2006)

Molecular and Cellular Pathways Contributing to Joint Damage in Rheumatoid Arthritis
por: Fang, Qinghua, et al.
Publicado: (2020)

Autoantibodies as Diagnostic Markers and Mediator of Joint Inflammation in Arthritis
por: Fang, Qinghua, et al.
Publicado: (2019)

A Perspective on Oral Immunotherapeutic Tools and Strategies for Autoimmune Disorders
por: Shakya, Akhilesh Kumar, et al.
Publicado: (2023)

Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells
por: Nandakumar, Kutty Selva, et al.
Publicado: (2004)

Human NCF1(90H) Variant Promotes IL-23/IL-17—Dependent Mannan-Induced Psoriasis and Psoriatic Arthritis
por: Li, Yanpeng, et al.
Publicado: (2023)

Induction of Potent Antigen-specific Cytotoxic T Cell Response by PLGA-nanoparticles Containing Antigen and TLR Agonist
por: Lee, Young-Ran, et al.
Publicado: (2013)

Development of N-Acetylated Dipalmitoyl-S-Glyceryl Cysteine Analogs as Efficient TLR2/TLR6 Agonists
por: Zhou, Yang, et al.
Publicado: (2019)

Deoxyguanosine is a TLR7 agonist
por: Davenne, Tamara, et al.
Publicado: (2019)

NOD2 Agonist Promotes the Production of Inflammatory Cytokines in VSMC in Synergy with TLR2 and TLR4 Agonists
por: Sun, Jinghua, et al.
Publicado: (2012)

BAX as the mediator of C-MYC sensitizes acute lymphoblastic leukemia to TLR9 agonists
por: Bai, Ling, et al.
Publicado: (2023)

Cytotoxic T Lymphocytes and Vaccine Development
por: Xiao, Zhengguo, et al.
Publicado: (2010)

Novel TLR 7/8 agonists for improving NK cell mediated antibody-dependent cellular cytotoxicity (ADCC)
por: Khanna, Vidhi, et al.
Publicado: (2021)

A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation
por: Marshall, Jason D., et al.
Publicado: (2016)

In-vitro Modulation of mTOR-HIF-1α Axis by TLR7/8 Agonist (Resiquimod) in B-Chronic Lymphocytic Leukemia
por: Hanafy, Rana M., et al.
Publicado: (2023)

A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 Vaccines
por: Zhang, Naru, et al.
Publicado: (2022)

Comparative studies on mannan and imiquimod induced experimental plaque psoriasis inflammation in inbred mice
por: Wu, Huimei, et al.
Publicado: (2023)

Aberrant Activation of Immune and Non-Immune Cells Contributes to Joint Inflammation and Bone Degradation in Rheumatoid Arthritis
por: Nandakumar, Kutty Selva, et al.
Publicado: (2023)

Development of a novel TLR8 agonist for cancer immunotherapy
por: Wang, Yuxun, et al.
Publicado: (2020)

Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes
Publicado: (1987)

Effects of TLR agonists on immune responses in Trichinella spiralis infected mice
por: Tang, Bin, et al.
Publicado: (2020)

Comparison of human B cell activation by TLR7 and TLR9 agonists
por: Hanten, John A, et al.
Publicado: (2008)

Trial Watch: experimental TLR7/TLR8 agonists for oncological indications
por: Frega, Giorgio, et al.
Publicado: (2020)

Combined TLR2/4-Activated Dendritic/Tumor Cell Fusions Induce Augmented Cytotoxic T Lymphocytes
por: Koido, Shigeo, et al.
Publicado: (2013)

Expression of TLR2, TLR3, TLR4, and TLR7 on pulmonary lymphocytes of Schistosoma japonicum-infected C57BL/6 mice
por: Chen, Dianhui, et al.
Publicado: (2019)

Aberrant Expression of TLR2, TLR7, TLR9, Splicing Variants of TLR4 and MYD88 in Chronic Lymphocytic Leukemia Patients
por: Skorka, Katarzyna, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lhd3romj2e8b28v5jbacr6vpcl