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The Elaboration of miRNA Regulation and Gene Regulatory Networks in Plant–Microbe Interactions

Plants are exposed to diverse abiotic and biotic stimuli. These require fast and specific integrated responses. Such responses are coordinated at the protein and transcript levels and are incorporated into larger regulatory networks. Here, we focus on the evolution of transcriptional regulatory netw...

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Autores principales: de Vries, Sophie, de Vries, Jan, Rose, Laura E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523410/
https://www.ncbi.nlm.nih.gov/pubmed/31010062
http://dx.doi.org/10.3390/genes10040310
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author de Vries, Sophie
de Vries, Jan
Rose, Laura E.
author_facet de Vries, Sophie
de Vries, Jan
Rose, Laura E.
author_sort de Vries, Sophie
collection PubMed
description Plants are exposed to diverse abiotic and biotic stimuli. These require fast and specific integrated responses. Such responses are coordinated at the protein and transcript levels and are incorporated into larger regulatory networks. Here, we focus on the evolution of transcriptional regulatory networks involved in plant–pathogen interactions. We discuss the evolution of regulatory networks and their role in fine-tuning plant defense responses. Based on the observation that many of the cornerstones of immune signaling in angiosperms are also present in streptophyte algae, it is likely that some regulatory components also predate the origin of land plants. The degree of functional conservation of many of these ancient components has not been elucidated. However, ongoing functional analyses in bryophytes show that some components are conserved. Hence, some of these regulatory components and how they are wired may also trace back to the last common ancestor of land plants or earlier. Of course, an understanding of the similarities and differences during the evolution of plant defense networks cannot ignore the lineage-specific coevolution between plants and their pathogens. In this review, we specifically focus on the small RNA regulatory networks involved in fine-tuning of the strength and timing of defense responses and highlight examples of pathogen exploitation of the host RNA silencing system. These examples illustrate well how pathogens frequently target gene regulation and thereby alter immune responses on a larger scale. That this is effective is demonstrated by the diversity of pathogens from distinct kingdoms capable of manipulating the same gene regulatory networks, such as the RNA silencing machinery.
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spelling pubmed-65234102019-06-03 The Elaboration of miRNA Regulation and Gene Regulatory Networks in Plant–Microbe Interactions de Vries, Sophie de Vries, Jan Rose, Laura E. Genes (Basel) Review Plants are exposed to diverse abiotic and biotic stimuli. These require fast and specific integrated responses. Such responses are coordinated at the protein and transcript levels and are incorporated into larger regulatory networks. Here, we focus on the evolution of transcriptional regulatory networks involved in plant–pathogen interactions. We discuss the evolution of regulatory networks and their role in fine-tuning plant defense responses. Based on the observation that many of the cornerstones of immune signaling in angiosperms are also present in streptophyte algae, it is likely that some regulatory components also predate the origin of land plants. The degree of functional conservation of many of these ancient components has not been elucidated. However, ongoing functional analyses in bryophytes show that some components are conserved. Hence, some of these regulatory components and how they are wired may also trace back to the last common ancestor of land plants or earlier. Of course, an understanding of the similarities and differences during the evolution of plant defense networks cannot ignore the lineage-specific coevolution between plants and their pathogens. In this review, we specifically focus on the small RNA regulatory networks involved in fine-tuning of the strength and timing of defense responses and highlight examples of pathogen exploitation of the host RNA silencing system. These examples illustrate well how pathogens frequently target gene regulation and thereby alter immune responses on a larger scale. That this is effective is demonstrated by the diversity of pathogens from distinct kingdoms capable of manipulating the same gene regulatory networks, such as the RNA silencing machinery. MDPI 2019-04-21 /pmc/articles/PMC6523410/ /pubmed/31010062 http://dx.doi.org/10.3390/genes10040310 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
de Vries, Sophie
de Vries, Jan
Rose, Laura E.
The Elaboration of miRNA Regulation and Gene Regulatory Networks in Plant–Microbe Interactions
title The Elaboration of miRNA Regulation and Gene Regulatory Networks in Plant–Microbe Interactions
title_full The Elaboration of miRNA Regulation and Gene Regulatory Networks in Plant–Microbe Interactions
title_fullStr The Elaboration of miRNA Regulation and Gene Regulatory Networks in Plant–Microbe Interactions
title_full_unstemmed The Elaboration of miRNA Regulation and Gene Regulatory Networks in Plant–Microbe Interactions
title_short The Elaboration of miRNA Regulation and Gene Regulatory Networks in Plant–Microbe Interactions
title_sort elaboration of mirna regulation and gene regulatory networks in plant–microbe interactions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523410/
https://www.ncbi.nlm.nih.gov/pubmed/31010062
http://dx.doi.org/10.3390/genes10040310
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