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Pluronic F127-Folate Coated Super Paramagenic Iron Oxide Nanoparticles as Contrast Agent for Cancer Diagnosis in Magnetic Resonance Imaging

Contrast agents have been widely used in medicine to enhance contrast in magnetic resonance imaging (MRI). Among them, super paramagnetic iron oxide nanoparticles (SPION) have been reported to have low risk in clinical use. In our study, F127-Folate coated SPION was fabricated in order to efficientl...

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Autores principales: Vu-Quang, Hieu, Vinding, Mads Sloth, Nielsen, Thomas, Ullisch, Marcus Görge, Nielsen, Niels Chr., Nguyen, Dinh-Truong, Kjems, Jørgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523503/
https://www.ncbi.nlm.nih.gov/pubmed/31027171
http://dx.doi.org/10.3390/polym11040743
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author Vu-Quang, Hieu
Vinding, Mads Sloth
Nielsen, Thomas
Ullisch, Marcus Görge
Nielsen, Niels Chr.
Nguyen, Dinh-Truong
Kjems, Jørgen
author_facet Vu-Quang, Hieu
Vinding, Mads Sloth
Nielsen, Thomas
Ullisch, Marcus Görge
Nielsen, Niels Chr.
Nguyen, Dinh-Truong
Kjems, Jørgen
author_sort Vu-Quang, Hieu
collection PubMed
description Contrast agents have been widely used in medicine to enhance contrast in magnetic resonance imaging (MRI). Among them, super paramagnetic iron oxide nanoparticles (SPION) have been reported to have low risk in clinical use. In our study, F127-Folate coated SPION was fabricated in order to efficiently target tumors and provide imaging contrast in MRI. SPION alone have an average core size of 15 nm. After stabilizing with Pluronic F127, the nanoparticles reached a hydrodynamic size of 180 nm and dispersed well in various kinds of media. The F127-Folate coated SPION were shown to specifically target folate receptor expressing cancer cells by flow cytometry analysis, confocal laser scanning microscope, as well as in vitro MRI. Furthermore, in vivo MRI images have shown the enhanced negative contrast from the F127-Folate coated SPION in tumor-bearing mice. In conclusion, our F127-Folate coated SPION have shown great potential as a contrast agent in MRI, as well as in the combination with drug delivery for cancer therapy.
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spelling pubmed-65235032019-06-03 Pluronic F127-Folate Coated Super Paramagenic Iron Oxide Nanoparticles as Contrast Agent for Cancer Diagnosis in Magnetic Resonance Imaging Vu-Quang, Hieu Vinding, Mads Sloth Nielsen, Thomas Ullisch, Marcus Görge Nielsen, Niels Chr. Nguyen, Dinh-Truong Kjems, Jørgen Polymers (Basel) Article Contrast agents have been widely used in medicine to enhance contrast in magnetic resonance imaging (MRI). Among them, super paramagnetic iron oxide nanoparticles (SPION) have been reported to have low risk in clinical use. In our study, F127-Folate coated SPION was fabricated in order to efficiently target tumors and provide imaging contrast in MRI. SPION alone have an average core size of 15 nm. After stabilizing with Pluronic F127, the nanoparticles reached a hydrodynamic size of 180 nm and dispersed well in various kinds of media. The F127-Folate coated SPION were shown to specifically target folate receptor expressing cancer cells by flow cytometry analysis, confocal laser scanning microscope, as well as in vitro MRI. Furthermore, in vivo MRI images have shown the enhanced negative contrast from the F127-Folate coated SPION in tumor-bearing mice. In conclusion, our F127-Folate coated SPION have shown great potential as a contrast agent in MRI, as well as in the combination with drug delivery for cancer therapy. MDPI 2019-04-25 /pmc/articles/PMC6523503/ /pubmed/31027171 http://dx.doi.org/10.3390/polym11040743 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vu-Quang, Hieu
Vinding, Mads Sloth
Nielsen, Thomas
Ullisch, Marcus Görge
Nielsen, Niels Chr.
Nguyen, Dinh-Truong
Kjems, Jørgen
Pluronic F127-Folate Coated Super Paramagenic Iron Oxide Nanoparticles as Contrast Agent for Cancer Diagnosis in Magnetic Resonance Imaging
title Pluronic F127-Folate Coated Super Paramagenic Iron Oxide Nanoparticles as Contrast Agent for Cancer Diagnosis in Magnetic Resonance Imaging
title_full Pluronic F127-Folate Coated Super Paramagenic Iron Oxide Nanoparticles as Contrast Agent for Cancer Diagnosis in Magnetic Resonance Imaging
title_fullStr Pluronic F127-Folate Coated Super Paramagenic Iron Oxide Nanoparticles as Contrast Agent for Cancer Diagnosis in Magnetic Resonance Imaging
title_full_unstemmed Pluronic F127-Folate Coated Super Paramagenic Iron Oxide Nanoparticles as Contrast Agent for Cancer Diagnosis in Magnetic Resonance Imaging
title_short Pluronic F127-Folate Coated Super Paramagenic Iron Oxide Nanoparticles as Contrast Agent for Cancer Diagnosis in Magnetic Resonance Imaging
title_sort pluronic f127-folate coated super paramagenic iron oxide nanoparticles as contrast agent for cancer diagnosis in magnetic resonance imaging
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523503/
https://www.ncbi.nlm.nih.gov/pubmed/31027171
http://dx.doi.org/10.3390/polym11040743
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