Smart Mesoporous Silica Nanoparticles for Protein Delivery

Mesoporous silica nanoparticles (MSN) have attracted a lot of attention during the past decade which is attributable to their versatile and high loading capacity, easy surface functionalization, excellent biocompatibility, and great physicochemical and thermal stability. In this review, we discuss t...

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Detalles Bibliográficos
Autores principales: Liu, Hai-Jun, Xu, Peisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523670/
https://www.ncbi.nlm.nih.gov/pubmed/30986952
http://dx.doi.org/10.3390/nano9040511
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author Liu, Hai-Jun
Xu, Peisheng
author_facet Liu, Hai-Jun
Xu, Peisheng
author_sort Liu, Hai-Jun
collection PubMed
description Mesoporous silica nanoparticles (MSN) have attracted a lot of attention during the past decade which is attributable to their versatile and high loading capacity, easy surface functionalization, excellent biocompatibility, and great physicochemical and thermal stability. In this review, we discuss the factors affecting the loading of protein into MSN and general strategies for targeted delivery and controlled release of proteins with MSN. Additionally, we also give an outlook for the remaining challenges in the clinical translation of protein-loaded MSNs.
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spelling pubmed-65236702019-06-03 Smart Mesoporous Silica Nanoparticles for Protein Delivery Liu, Hai-Jun Xu, Peisheng Nanomaterials (Basel) Review Mesoporous silica nanoparticles (MSN) have attracted a lot of attention during the past decade which is attributable to their versatile and high loading capacity, easy surface functionalization, excellent biocompatibility, and great physicochemical and thermal stability. In this review, we discuss the factors affecting the loading of protein into MSN and general strategies for targeted delivery and controlled release of proteins with MSN. Additionally, we also give an outlook for the remaining challenges in the clinical translation of protein-loaded MSNs. MDPI 2019-04-02 /pmc/articles/PMC6523670/ /pubmed/30986952 http://dx.doi.org/10.3390/nano9040511 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liu, Hai-Jun
Xu, Peisheng
Smart Mesoporous Silica Nanoparticles for Protein Delivery
title Smart Mesoporous Silica Nanoparticles for Protein Delivery
title_full Smart Mesoporous Silica Nanoparticles for Protein Delivery
title_fullStr Smart Mesoporous Silica Nanoparticles for Protein Delivery
title_full_unstemmed Smart Mesoporous Silica Nanoparticles for Protein Delivery
title_short Smart Mesoporous Silica Nanoparticles for Protein Delivery
title_sort smart mesoporous silica nanoparticles for protein delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523670/
https://www.ncbi.nlm.nih.gov/pubmed/30986952
http://dx.doi.org/10.3390/nano9040511
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