Cargando…

Nanocarriers for Protein Delivery to the Cytosol: Assessing the Endosomal Escape of Poly(Lactide-co-Glycolide)-Poly(Ethylene Imine) Nanoparticles

Therapeutic proteins and enzymes are a group of interesting candidates for the treatment of numerous diseases, but they often require a carrier to avoid degradation and rapid clearance in vivo. To this end, organic nanoparticles (NPs) represent an excellent choice due to their biocompatibility, and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Galliani, Marianna, Tremolanti, Chiara, Signore, Giovanni
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523739/ https://www.ncbi.nlm.nih.gov/pubmed/31018628 http://dx.doi.org/10.3390/nano9040652

Ejemplares similares

The Design of Poly(lactide-co-glycolide) Nanocarriers for Medical Applications
por: Essa, Divesha, et al.
Publicado: (2020)

Rational Mitomycin Nanocarriers Based on Hydrophobically Functionalized Polyelectrolytes and Poly(lactide-co-glycolide)
por: Lamch, Łukasz, et al.
Publicado: (2022)

Primary biocompatibility tests of poly(lactide-co-glycolide)-(poly-L-orithine/fucoidan) core–shell nanocarriers
por: Cai, Duanhua, et al.
Publicado: (2018)

Preparation and Evaluation of Poly(Ethylene Glycol)–Poly(Lactide) Micelles as Nanocarriers for Oral Delivery of Cyclosporine A
por: Zhang, Yanhui, et al.
Publicado: (2010)

Facile Hydrophobication of Glutathione-Protected Gold Nanoclusters and Encapsulation into Poly(lactide-co-glycolide) Nanocarriers
por: Alkilany, Alaaldin M., et al.
Publicado: (2019)

Structures and Applications of Thermoresponsive Hydrogels and Nanocomposite-Hydrogels Based on Copolymers with Poly (Ethylene Glycol) and Poly (Lactide-Co-Glycolide) Blocks
por: Maeda, Tomoki
Publicado: (2019)

Biodegradable membrane of poly(l-lactide acid-dioxanone-glycolide) and stereocomplex poly(lactide) with enhanced crystallization and biocompatibility
por: Fan, Tiantang, et al.
Publicado: (2022)

A Dual-sensitive Hydrogel Based on Poly(Lactide-co-Glycolide)-Polyethylene Glycol-Poly(Lactide-co-Glycolide) Block Copolymers for 3D Printing
por: Zhou, Yang, et al.
Publicado: (2021)

Ciprofloxacin-Releasing ROS-Sensitive Nanoparticles Composed of Poly(Ethylene Glycol)/Poly(D,L-lactide-co-glycolide) for Antibacterial Treatment
por: Song, Jaeik, et al.
Publicado: (2021)

Safety of poly (ethylene glycol)-coated perfluorodecalin-filled poly (lactide-co-glycolide) microcapsules following intravenous administration of high amounts in rats
por: Ferenz, Katja B., et al.
Publicado: (2014)

Imparting Superhydrophobicity to Biodegradable Poly(lactide-co-glycolide) Electrospun Meshes
por: Kaplan, Jonah A., et al.
Publicado: (2014)

Preparation, characterization, and safety evaluation of poly(lactide-co-glycolide) nanoparticles for protein delivery into macrophages
por: Guedj, Anne-Sophie, et al.
Publicado: (2015)

Idarubicin-loaded methoxy poly(ethylene glycol)-b-poly(l-lactide-co-glycolide) nanoparticles for enhancing cellular uptake and promoting antileukemia activity
por: Liang, Bin, et al.
Publicado: (2019)

Influence of Hydroxyapatite Surface Functionalization on Thermal and Biological Properties of Poly(l-Lactide)- and Poly(l-Lactide-co-Glycolide)-Based Composites
por: Gazińska, Małgorzata, et al.
Publicado: (2020)

Double-Walled Poly-(D,L-lactide-co-glycolide) (PLGA) and Poly(L-lactide) (PLLA) Nanoparticles for the Sustained Release of Doxorubicin
por: Cardoso, M. Margarida, et al.
Publicado: (2021)

Poly(lactide-co-glycolide)/Hydroxyapatite Porous Scaffold with Microchannels for Bone Regeneration
por: Zhang, Ning, et al.
Publicado: (2016)

Microencapsulation of Thymol in Poly(lactide-co-glycolide) (PLGA): Physical and Antibacterial Properties
por: Zhu, Zhu, et al.
Publicado: (2019)

pH-sensitive poly(lactide-co-glycolide) nanoparticle composite microcapsules for oral delivery of insulin
por: Sun, Shaoping, et al.
Publicado: (2015)

Enhanced antibacterial activity of roxithromycin loaded pegylated poly lactide-co-glycolide nanoparticles
por: Koopaei, Mona Noori, et al.
Publicado: (2012)

Definition and validation of operating equations for poly(vinyl alcohol)-poly(lactide-co-glycolide) microfiltration membrane-scaffold bioreactors
por: Shipley, RJ, et al.
Publicado: (2010)

Biodegradable Scaffolds for Vascular Regeneration Based on Electrospun Poly(L-Lactide-co-Glycolide)/Poly(Isosorbide Sebacate) Fibers
por: Śmiga-Matuszowicz, Monika, et al.
Publicado: (2023)

Designing Biodegradable Wafers Based on Poly(L-lactide-co-glycolide) and Poly(glycolide-co-ε-caprolactone) for the Prolonged and Local Release of Idarubicin for the Therapy of Glioblastoma Multiforme
por: Turek, Artur, et al.
Publicado: (2020)

Poly(l-lactide-co-caprolactone-co-glycolide)-Based Nanoparticles as Delivery Platform: Effect of the Surfactants on Characteristics and Delivery Efficiency
por: Rebanda, Magda M., et al.
Publicado: (2022)

Optimization and Designing of Amikacin-loaded Poly D, L-Lactide-co-glycolide Nanoparticles for Effective and Sustained Drug Delivery
por: Fatima, Saman, et al.
Publicado: (2019)

Arginine-Modified Polymers Facilitate Poly (Lactide-Co-Glycolide)-Based Nanoparticle Gene Delivery to Primary Human Astrocytes
por: Proulx, Jessica, et al.
Publicado: (2020)

Biodegradable nanoparticles of methoxy poly(ethylene glycol)-b-poly( d, l-lactide)/methoxy poly(ethylene glycol)- b-poly(ϵ-caprolactone) blends for drug delivery
por: Baimark, Yodthong, et al.
Publicado: (2012)

Preparation and Characterization of Poly(D,L-Lactide-co-Glycolide) Nanoparticles Containing Ascorbic Acid
por: Stevanović, Magdalena M., et al.
Publicado: (2007)

Poly(d,l-lactide-co-glycolide)–chitosan composite particles for the treatment of lung cancer
por: Arya, Neha, et al.
Publicado: (2015)

Glycosaminoglycan-functionalized poly-lactide-co-glycolide nanoparticles: synthesis, characterization, cytocompatibility, and cellular uptake
por: Lamichhane, Surya P, et al.
Publicado: (2015)

Preparation, Characterization, and In Vivo Evaluation of Olanzapine Poly(D,L-lactide-co-glycolide) Microspheres
por: D'Souza, Susan, et al.
Publicado: (2013)

Controlled Release of Lysozyme from Double-Walled Poly(Lactide-Co-Glycolide) (PLGA) Microspheres
por: Ansary, Rezaul H., et al.
Publicado: (2017)

Statistical degradation modelling of Poly(D,L-lactide-co-glycolide) copolymers for bioscaffold applications
por: Robles-Bykbaev, Yaroslava, et al.
Publicado: (2018)

Encapsulation of Andrographolide in poly(lactide-co-glycolide) Nanoparticles: Formulation Optimization and in vitro Efficacy Studies
por: Oseni, Bukola A., et al.
Publicado: (2021)

Degradation Behavior of Poly(Lactide-Co-Glycolide) Monolayers Investigated by Langmuir Technique: Accelerating Effect
por: Kim, Gayeon, et al.
Publicado: (2023)

Surface Functionalization of Poly(l-lactide-co-glycolide) Membranes with RGD-Grafted Poly(2-oxazoline) for Periodontal Tissue Engineering
por: Tryba, Anna M., et al.
Publicado: (2022)

Design and Evaluation of a Poly(Lactide-co-Glycolide)-Based In Situ Film-Forming System for Topical Delivery of Trolamine Salicylate
por: Kim, Yujin, et al.
Publicado: (2019)

Chitosan-modified poly(d,l-lactide-co-glycolide) nanospheres for improving siRNA delivery and gene-silencing effects
por: Tahara, Kohei, et al.
Publicado: (2010)

Novel docetaxel-loaded nanoparticles based on poly(lactide-co-caprolactone) and poly(lactide-co-glycolide-co-caprolactone) for prostate cancer treatment: formulation, characterization, and cytotoxicity studies
por: Sanna, Vanna, et al.
Publicado: (2011)

Pranoprofen Nanoparticles With Poly(L-Lactide)-b-Poly(Ethylene Glycol)-b-Poly(L-Lactide) as the Matrix Toward Improving Ocular Anti-inflammation
por: Luo, Yang, et al.
Publicado: (2020)

Doxorubicin-incorporated polymeric micelles composed of dextran-b-poly(DL-lactide-co-glycolide) copolymer
por: Jeong, Young-Il, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_6blncchup7pfhl8hg34q1mlfdb