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Reliability of Fronto–Amygdala Coupling during Emotional Face Processing

One of the most exciting translational prospects for brain imaging research is the potential use of functional magnetic resonance imaging (fMRI) ‘biomarkers’ to predict an individual’s risk of developing a neuropsychiatric disorder or the likelihood of responding to a particular intervention. This p...

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Autores principales: Nord, Camilla L, Gray, Alan, Robinson, Oliver J, Roiser, Jonathan P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523743/
https://www.ncbi.nlm.nih.gov/pubmed/31010224
http://dx.doi.org/10.3390/brainsci9040089
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author Nord, Camilla L
Gray, Alan
Robinson, Oliver J
Roiser, Jonathan P
author_facet Nord, Camilla L
Gray, Alan
Robinson, Oliver J
Roiser, Jonathan P
author_sort Nord, Camilla L
collection PubMed
description One of the most exciting translational prospects for brain imaging research is the potential use of functional magnetic resonance imaging (fMRI) ‘biomarkers’ to predict an individual’s risk of developing a neuropsychiatric disorder or the likelihood of responding to a particular intervention. This proposal depends critically on reliable measurements at the level of the individual. Several previous studies have reported relatively poor reliability of amygdala activation during emotional face processing, a key putative fMRI ‘biomarker’. However, the reliability of amygdala connectivity measures is much less well understood. Here, we assessed the reliability of task-modulated coupling between three seed regions (left and right amygdala and the subgenual anterior cingulate cortex) and the dorsomedial frontal/cingulate cortex (DMFC), measured using a psychophysiological interaction analysis in 29 healthy individuals scanned approximately two weeks apart. We performed two runs on each day of three different emotional face-processing tasks: emotion identification, emotion matching, and gender classification. We tested both between-day reliability and within-day (between-run) reliability. We found good-to-excellent within-subject reliability of amygdala–DMFC coupling, both between days (in two tasks), and within day (in one task). This suggests that disorder-relevant regional coupling may be sufficiently reliable to be used as a predictor of treatment response or clinical risk in future clinical studies.
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spelling pubmed-65237432019-06-03 Reliability of Fronto–Amygdala Coupling during Emotional Face Processing Nord, Camilla L Gray, Alan Robinson, Oliver J Roiser, Jonathan P Brain Sci Article One of the most exciting translational prospects for brain imaging research is the potential use of functional magnetic resonance imaging (fMRI) ‘biomarkers’ to predict an individual’s risk of developing a neuropsychiatric disorder or the likelihood of responding to a particular intervention. This proposal depends critically on reliable measurements at the level of the individual. Several previous studies have reported relatively poor reliability of amygdala activation during emotional face processing, a key putative fMRI ‘biomarker’. However, the reliability of amygdala connectivity measures is much less well understood. Here, we assessed the reliability of task-modulated coupling between three seed regions (left and right amygdala and the subgenual anterior cingulate cortex) and the dorsomedial frontal/cingulate cortex (DMFC), measured using a psychophysiological interaction analysis in 29 healthy individuals scanned approximately two weeks apart. We performed two runs on each day of three different emotional face-processing tasks: emotion identification, emotion matching, and gender classification. We tested both between-day reliability and within-day (between-run) reliability. We found good-to-excellent within-subject reliability of amygdala–DMFC coupling, both between days (in two tasks), and within day (in one task). This suggests that disorder-relevant regional coupling may be sufficiently reliable to be used as a predictor of treatment response or clinical risk in future clinical studies. MDPI 2019-04-19 /pmc/articles/PMC6523743/ /pubmed/31010224 http://dx.doi.org/10.3390/brainsci9040089 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nord, Camilla L
Gray, Alan
Robinson, Oliver J
Roiser, Jonathan P
Reliability of Fronto–Amygdala Coupling during Emotional Face Processing
title Reliability of Fronto–Amygdala Coupling during Emotional Face Processing
title_full Reliability of Fronto–Amygdala Coupling during Emotional Face Processing
title_fullStr Reliability of Fronto–Amygdala Coupling during Emotional Face Processing
title_full_unstemmed Reliability of Fronto–Amygdala Coupling during Emotional Face Processing
title_short Reliability of Fronto–Amygdala Coupling during Emotional Face Processing
title_sort reliability of fronto–amygdala coupling during emotional face processing
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523743/
https://www.ncbi.nlm.nih.gov/pubmed/31010224
http://dx.doi.org/10.3390/brainsci9040089
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