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CRISP-R/Cas9 Mediated Deletion of Copper Transport Genes CTR1 and DMT1 in NSCLC Cell Line H1299. Biological and Pharmacological Consequences

Copper, the highly toxic micronutrient, plays two essential roles: it is a catalytic and structural cofactor for Cu-dependent enzymes, and it acts as a secondary messenger. In the cells, copper is imported by CTR1 (high-affinity copper transporter 1), a transmembrane high-affinity copper importer, a...

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Detalles Bibliográficos
Autores principales:	Ilyechova, Ekaterina Y., Bonaldi, Elisa, Orlov, Iurii A., Skomorokhova, Ekaterina A., Puchkova, Ludmila V., Broggini, Massimo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523758/ https://www.ncbi.nlm.nih.gov/pubmed/30959888 http://dx.doi.org/10.3390/cells8040322

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