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Microbiome—Microbial Metabolome—Cancer Cell Interactions in Breast Cancer—Familiar, but Unexplored
Breast cancer is a leading cause of death among women worldwide. Dysbiosis, an aberrant composition of the microbiome, characterizes breast cancer. In this review we discuss the changes to the metabolism of breast cancer cells, as well as the composition of the breast and gut microbiome in breast ca...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523810/ https://www.ncbi.nlm.nih.gov/pubmed/30934972 http://dx.doi.org/10.3390/cells8040293 |
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author | Mikó, Edit Kovács, Tünde Sebő, Éva Tóth, Judit Csonka, Tamás Ujlaki, Gyula Sipos, Adrienn Szabó, Judit Méhes, Gábor Bai, Péter |
author_facet | Mikó, Edit Kovács, Tünde Sebő, Éva Tóth, Judit Csonka, Tamás Ujlaki, Gyula Sipos, Adrienn Szabó, Judit Méhes, Gábor Bai, Péter |
author_sort | Mikó, Edit |
collection | PubMed |
description | Breast cancer is a leading cause of death among women worldwide. Dysbiosis, an aberrant composition of the microbiome, characterizes breast cancer. In this review we discuss the changes to the metabolism of breast cancer cells, as well as the composition of the breast and gut microbiome in breast cancer. The role of the breast microbiome in breast cancer is unresolved, nevertheless it seems that the gut microbiome does have a role in the pathology of the disease. The gut microbiome secretes bioactive metabolites (reactivated estrogens, short chain fatty acids, amino acid metabolites, or secondary bile acids) that modulate breast cancer. We highlight the bacterial species or taxonomical units that generate these metabolites, we show their mode of action, and discuss how the metabolites affect mitochondrial metabolism and other molecular events in breast cancer. These metabolites resemble human hormones, as they are produced in a “gland” (in this case, the microbiome) and they are subsequently transferred to distant sites of action through the circulation. These metabolites appear to be important constituents of the tumor microenvironment. Finally, we discuss how bacterial dysbiosis interferes with breast cancer treatment through interfering with chemotherapeutic drug metabolism and availability. |
format | Online Article Text |
id | pubmed-6523810 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65238102019-06-03 Microbiome—Microbial Metabolome—Cancer Cell Interactions in Breast Cancer—Familiar, but Unexplored Mikó, Edit Kovács, Tünde Sebő, Éva Tóth, Judit Csonka, Tamás Ujlaki, Gyula Sipos, Adrienn Szabó, Judit Méhes, Gábor Bai, Péter Cells Review Breast cancer is a leading cause of death among women worldwide. Dysbiosis, an aberrant composition of the microbiome, characterizes breast cancer. In this review we discuss the changes to the metabolism of breast cancer cells, as well as the composition of the breast and gut microbiome in breast cancer. The role of the breast microbiome in breast cancer is unresolved, nevertheless it seems that the gut microbiome does have a role in the pathology of the disease. The gut microbiome secretes bioactive metabolites (reactivated estrogens, short chain fatty acids, amino acid metabolites, or secondary bile acids) that modulate breast cancer. We highlight the bacterial species or taxonomical units that generate these metabolites, we show their mode of action, and discuss how the metabolites affect mitochondrial metabolism and other molecular events in breast cancer. These metabolites resemble human hormones, as they are produced in a “gland” (in this case, the microbiome) and they are subsequently transferred to distant sites of action through the circulation. These metabolites appear to be important constituents of the tumor microenvironment. Finally, we discuss how bacterial dysbiosis interferes with breast cancer treatment through interfering with chemotherapeutic drug metabolism and availability. MDPI 2019-03-29 /pmc/articles/PMC6523810/ /pubmed/30934972 http://dx.doi.org/10.3390/cells8040293 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mikó, Edit Kovács, Tünde Sebő, Éva Tóth, Judit Csonka, Tamás Ujlaki, Gyula Sipos, Adrienn Szabó, Judit Méhes, Gábor Bai, Péter Microbiome—Microbial Metabolome—Cancer Cell Interactions in Breast Cancer—Familiar, but Unexplored |
title | Microbiome—Microbial Metabolome—Cancer Cell Interactions in Breast Cancer—Familiar, but Unexplored |
title_full | Microbiome—Microbial Metabolome—Cancer Cell Interactions in Breast Cancer—Familiar, but Unexplored |
title_fullStr | Microbiome—Microbial Metabolome—Cancer Cell Interactions in Breast Cancer—Familiar, but Unexplored |
title_full_unstemmed | Microbiome—Microbial Metabolome—Cancer Cell Interactions in Breast Cancer—Familiar, but Unexplored |
title_short | Microbiome—Microbial Metabolome—Cancer Cell Interactions in Breast Cancer—Familiar, but Unexplored |
title_sort | microbiome—microbial metabolome—cancer cell interactions in breast cancer—familiar, but unexplored |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523810/ https://www.ncbi.nlm.nih.gov/pubmed/30934972 http://dx.doi.org/10.3390/cells8040293 |
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