Small-Molecule Host-Defense Peptide Mimetic Antibacterial and Antifungal Agents Activate Human and Mouse Mast Cells via Mas-Related GPCRs

Host-defense peptides (HDPs) have an important therapeutic potential against microbial infections but their metabolic instability and cellular cytotoxicity have limited their utility. To overcome these limitations, we utilized five small-molecule, nonpeptide HDP mimetics (smHDPMs) and tested their e...

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Detalles Bibliográficos
Autores principales: Alkanfari, Ibrahim, Freeman, Katie B., Roy, Saptarshi, Jahan, Tahsin, Scott, Richard W., Ali, Hydar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523814/
https://www.ncbi.nlm.nih.gov/pubmed/30987258
http://dx.doi.org/10.3390/cells8040311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523814/
https://www.ncbi.nlm.nih.gov/pubmed/30987258
http://dx.doi.org/10.3390/cells8040311

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