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Mining for Oxysterols in Cyp7b1(−/−) Mouse Brain and Plasma: Relevance to Spastic Paraplegia Type 5

Deficiency in cytochrome P450 (CYP) 7B1, also known as oxysterol 7α-hydroxylase, in humans leads to hereditary spastic paraplegia type 5 (SPG5) and in some cases in infants to liver disease. SPG5 is medically characterized by loss of motor neurons in the corticospinal tract. In an effort to gain a b...

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Detalles Bibliográficos
Autores principales:	Meljon, Anna, Crick, Peter J., Yutuc, Eylan, Yau, Joyce L., Seckl, Jonathan R., Theofilopoulos, Spyridon, Arenas, Ernest, Wang, Yuqin, Griffiths, William J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523844/ https://www.ncbi.nlm.nih.gov/pubmed/31013940 http://dx.doi.org/10.3390/biom9040149

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