Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum

The most common cystic fibrosis-causing mutation (F508del, present in ~85% of CF patients) leads to CFTR misfolding, which is recognized by the endoplasmic reticulum (ER) quality control (ERQC), resulting in ER retention and early degradation. It is known that CFTR exit from the ER is mediated by sp...

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Detalles Bibliográficos
Autores principales: Santos, João D., Canato, Sara, Carvalho, Ana S., Botelho, Hugo M., Aloria, Kerman, Amaral, Margarida D., Matthiesen, Rune, Falcao, Andre O., Farinha, Carlos M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523853/
https://www.ncbi.nlm.nih.gov/pubmed/31014000
http://dx.doi.org/10.3390/cells8040353

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