Cargando…

mTOR Signalling in Head and Neck Cancer: Heads Up

The mammalian target of rapamycin (mTOR) signalling pathway is a central regulator of metabolism in all cells. It senses intracellular and extracellular signals and nutrient levels, and coordinates the metabolic requirements for cell growth, survival, and proliferation. Genetic alterations that dere...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tan, Fiona H., Bai, Yuchen, Saintigny, Pierre, Darido, Charbel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523933/ https://www.ncbi.nlm.nih.gov/pubmed/30970654 http://dx.doi.org/10.3390/cells8040333

Ejemplares similares

mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer
por: Gao, Wei, et al.
Publicado: (2012)

mTOR co-targeting strategies for head and neck cancer therapy
por: Wang, Zhiyong, et al.
Publicado: (2017)

Head and Neck Cancer Immunotherapy: Molecular Biological Aspects of Preclinical and Clinical Research
por: Chakraborty, Rajdeep, et al.
Publicado: (2023)

mTOR, metabolism, and the immune response in HPV-positive head and neck squamous cell cancer
por: Coppock, Joseph D., et al.
Publicado: (2016)

YBX1 integration of oncogenic PI3K/mTOR signalling regulates the fitness of malignant epithelial cells
por: Bai, Yuchen, et al.
Publicado: (2023)

Cortisol inhibits mTOR signaling in avascular necrosis of the femoral head
por: Liao, Yun, et al.
Publicado: (2017)

PD-L1 promotes head and neck squamous cell carcinoma cell growth through mTOR signaling
por: Zheng, Anyuan, et al.
Publicado: (2019)

Targeting mTOR-CCL20 Signaling May Improve Response to Docetaxel in Head and Neck Squamous Cell Carcinoma
por: Chou, Ming-Huei, et al.
Publicado: (2021)

PI3K/AKT/mTOR Signaling Pathway in HPV-Driven Head and Neck Carcinogenesis: Therapeutic Implications
por: Aguayo, Francisco, et al.
Publicado: (2023)

Anti-lymphangiogenic properties of mTOR inhibitors in head and neck squamous cell carcinoma experimental models
por: Ekshyyan, Oleksandr, et al.
Publicado: (2013)

Targeting PI3K/AKT/mTOR Signaling Pathway as a Radiosensitization in Head and Neck Squamous Cell Carcinomas
por: Su, Yu-Chieh, et al.
Publicado: (2022)

mTOR Co-Targeting in Cetuximab Resistance in Head and Neck Cancers Harboring PIK3CA and RAS Mutations
por: Wang, Zhiyong, et al.
Publicado: (2014)

mTOR signaling pathway and mTOR inhibitors in cancer: progress and challenges
por: Zou, Zhilin, et al.
Publicado: (2020)

Precision Medicine Approaches to Overcome Resistance to Therapy in Head and Neck Cancers
por: Ortiz-Cuaran, Sandra, et al.
Publicado: (2021)

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy
por: Tian, Tian, et al.
Publicado: (2019)

mTOR Signaling in Metabolism and Cancer
por: Huang, Shile
Publicado: (2020)

Impact of PI3K/AKT/mTOR pathway activation on the prognosis of patients with head and neck squamous cell carcinomas
por: García-Carracedo, Darío, et al.
Publicado: (2016)

The mTOR signaling pathway in cardiac aging
por: Dai, Dao-Fu, et al.
Publicado: (2023)

mTOR inhibitor use in head and neck squamous cell carcinoma: A meta‐analysis on survival, tumor response, and toxicity
por: Patel, Jaimin, et al.
Publicado: (2020)

Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer
por: Wang, Zhiyong, et al.
Publicado: (2021)

p-mTOR, p-ERK and PTEN Expression in Tumor Biopsies and Organoids as Predictive Biomarkers for Patients with HPV Negative Head and Neck Cancer
por: de Kort, W. W. B., et al.
Publicado: (2023)

The mTOR Signalling Pathway in Human Cancer
por: Pópulo, Helena, et al.
Publicado: (2012)

Loss of Grainy Head-Like 1 Is Associated with Disruption of the Epidermal Barrier and Squamous Cell Carcinoma of the Skin
por: Mlacki, Michal, et al.
Publicado: (2014)

Preclinical evaluation of dual PI3K-mTOR inhibitors and histone deacetylase inhibitors in head and neck squamous cell carcinoma
por: Erlich, R B, et al.
Publicado: (2012)

The dual PI3K/mTOR inhibitor PKI-587 enhances sensitivity to cetuximab in EGFR-resistant human head and neck cancer models
por: D'Amato, V, et al.
Publicado: (2014)

Control of mTOR Signaling by Ubiquitin
por: Jiang, Yao, et al.
Publicado: (2019)

Escaping mTOR inhibition for cancer therapy: Tumor suppressor functions of mTOR
por: Villar, Victor H., et al.
Publicado: (2017)

Targeting the Tumor Microenvironment through mTOR Inhibition and Chemotherapy as Induction Therapy for Locally Advanced Head and Neck Squamous Cell Carcinoma: The CAPRA Study
por: Evrard, Diane, et al.
Publicado: (2022)

The CDK4/6 inhibitor LY2835219 has potent activity in combination with mTOR inhibitor in head and neck squamous cell carcinoma
por: Ku, Bo Mi, et al.
Publicado: (2016)

mTOR signaling: implications for cancer and anticancer therapy
por: Petroulakis, E, et al.
Publicado: (2006)

mTOR Signaling in Cardiometabolic Disease, Cancer, and Aging
por: Das, Anindita, et al.
Publicado: (2017)

Nanotechnology-Based Targeting of mTOR Signaling in Cancer
por: Yoon, Mee-Sup
Publicado: (2020)

AAA + ATPase Thorase inhibits mTOR signaling through the disassembly of the mTOR complex 1
por: Umanah, George K. E., et al.
Publicado: (2022)

All PI3Kinase signaling is not mTOR: dissecting mTOR-dependent and independent signaling pathways in T cells
por: Gamper, Christopher J., et al.
Publicado: (2012)

mTOR-dependent signalling in Alzheimer's disease
por: Pei, Jin-Jing, et al.
Publicado: (2008)

SYK Regulates mTOR Signaling in AML
por: Carnevale, Julia, et al.
Publicado: (2013)

Roles of mTOR Signaling in Brain Development
por: Lee, Da Yong
Publicado: (2015)

Signaling crosstalk between the mTOR complexes
por: Xie, Jianling, et al.
Publicado: (2014)

mTOR signaling in skeletal development and disease
por: Chen, Jianquan, et al.
Publicado: (2018)

Experimental Approaches in Delineating mTOR Signaling
por: Qian, Jiayi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_pqa2151j3fi5iqpsreh25tgcrq