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Electrospinning Nanofibers for Therapeutics Delivery

The limitations of conventional therapeutic drugs necessitate the importance of developing novel therapeutics to treat diverse diseases. Conventional drugs have poor blood circulation time and are not stable or compatible with the biological system. Nanomaterials, with their exceptional structural p...

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Autores principales: Shahriar, S. M. Shatil, Mondal, Jagannath, Hasan, Mohammad Nazmul, Revuri, Vishnu, Lee, Dong Yun, Lee, Yong-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523943/
https://www.ncbi.nlm.nih.gov/pubmed/30987129
http://dx.doi.org/10.3390/nano9040532
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author Shahriar, S. M. Shatil
Mondal, Jagannath
Hasan, Mohammad Nazmul
Revuri, Vishnu
Lee, Dong Yun
Lee, Yong-Kyu
author_facet Shahriar, S. M. Shatil
Mondal, Jagannath
Hasan, Mohammad Nazmul
Revuri, Vishnu
Lee, Dong Yun
Lee, Yong-Kyu
author_sort Shahriar, S. M. Shatil
collection PubMed
description The limitations of conventional therapeutic drugs necessitate the importance of developing novel therapeutics to treat diverse diseases. Conventional drugs have poor blood circulation time and are not stable or compatible with the biological system. Nanomaterials, with their exceptional structural properties, have gained significance as promising materials for the development of novel therapeutics. Nanofibers with unique physiochemical and biological properties have gained significant attention in the field of health care and biomedical research. The choice of a wide variety of materials for nanofiber fabrication, along with the release of therapeutic payload in sustained and controlled release patterns, make nanofibers an ideal material for drug delivery research. Electrospinning is the conventional method for fabricating nanofibers with different morphologies and is often used for the mass production of nanofibers. This review highlights the recent advancements in the use of nanofibers for the delivery of therapeutic drugs, nucleic acids and growth factors. A detailed mechanism for fabricating different types of nanofiber produced from electrospinning, and factors influencing nanofiber generation, are discussed. The insights from this review can provide a thorough understanding of the precise selection of materials used for fabricating nanofibers for specific therapeutic applications and also the importance of nanofibers for drug delivery applications.
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spelling pubmed-65239432019-06-03 Electrospinning Nanofibers for Therapeutics Delivery Shahriar, S. M. Shatil Mondal, Jagannath Hasan, Mohammad Nazmul Revuri, Vishnu Lee, Dong Yun Lee, Yong-Kyu Nanomaterials (Basel) Review The limitations of conventional therapeutic drugs necessitate the importance of developing novel therapeutics to treat diverse diseases. Conventional drugs have poor blood circulation time and are not stable or compatible with the biological system. Nanomaterials, with their exceptional structural properties, have gained significance as promising materials for the development of novel therapeutics. Nanofibers with unique physiochemical and biological properties have gained significant attention in the field of health care and biomedical research. The choice of a wide variety of materials for nanofiber fabrication, along with the release of therapeutic payload in sustained and controlled release patterns, make nanofibers an ideal material for drug delivery research. Electrospinning is the conventional method for fabricating nanofibers with different morphologies and is often used for the mass production of nanofibers. This review highlights the recent advancements in the use of nanofibers for the delivery of therapeutic drugs, nucleic acids and growth factors. A detailed mechanism for fabricating different types of nanofiber produced from electrospinning, and factors influencing nanofiber generation, are discussed. The insights from this review can provide a thorough understanding of the precise selection of materials used for fabricating nanofibers for specific therapeutic applications and also the importance of nanofibers for drug delivery applications. MDPI 2019-04-03 /pmc/articles/PMC6523943/ /pubmed/30987129 http://dx.doi.org/10.3390/nano9040532 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shahriar, S. M. Shatil
Mondal, Jagannath
Hasan, Mohammad Nazmul
Revuri, Vishnu
Lee, Dong Yun
Lee, Yong-Kyu
Electrospinning Nanofibers for Therapeutics Delivery
title Electrospinning Nanofibers for Therapeutics Delivery
title_full Electrospinning Nanofibers for Therapeutics Delivery
title_fullStr Electrospinning Nanofibers for Therapeutics Delivery
title_full_unstemmed Electrospinning Nanofibers for Therapeutics Delivery
title_short Electrospinning Nanofibers for Therapeutics Delivery
title_sort electrospinning nanofibers for therapeutics delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523943/
https://www.ncbi.nlm.nih.gov/pubmed/30987129
http://dx.doi.org/10.3390/nano9040532
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