Cargando…
On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses
Eukaryotic genomes comprise a large proportion of repeated sequences, an important fraction of which are transposable elements (TEs). TEs are mobile elements that have a significant impact on genome evolution and on gene functioning. Although some TE insertions could provide adaptive advantages to s...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523952/ https://www.ncbi.nlm.nih.gov/pubmed/30935103 http://dx.doi.org/10.3390/genes10040258 |
_version_ | 1783419453728358400 |
---|---|
author | Lerat, Emmanuelle Casacuberta, Josep Chaparro, Cristian Vieira, Cristina |
author_facet | Lerat, Emmanuelle Casacuberta, Josep Chaparro, Cristian Vieira, Cristina |
author_sort | Lerat, Emmanuelle |
collection | PubMed |
description | Eukaryotic genomes comprise a large proportion of repeated sequences, an important fraction of which are transposable elements (TEs). TEs are mobile elements that have a significant impact on genome evolution and on gene functioning. Although some TE insertions could provide adaptive advantages to species, transposition is a highly mutagenic event that has to be tightly controlled to ensure its viability. Genomes have evolved sophisticated mechanisms to control TE activity, the most important being epigenetic silencing. However, the epigenetic control of TEs can also affect genes located nearby that can become epigenetically regulated. It has been proposed that the combination of TE mobilization and the induced changes in the epigenetic landscape could allow a rapid phenotypic adaptation to global environmental changes. In this review, we argue the crucial need to take into account the repeated part of genomes when studying the global impact of epigenetic modifications on an organism. We emphasize more particularly why it is important to carefully consider TEs and what bioinformatic tools can be used to do so. |
format | Online Article Text |
id | pubmed-6523952 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65239522019-06-03 On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses Lerat, Emmanuelle Casacuberta, Josep Chaparro, Cristian Vieira, Cristina Genes (Basel) Review Eukaryotic genomes comprise a large proportion of repeated sequences, an important fraction of which are transposable elements (TEs). TEs are mobile elements that have a significant impact on genome evolution and on gene functioning. Although some TE insertions could provide adaptive advantages to species, transposition is a highly mutagenic event that has to be tightly controlled to ensure its viability. Genomes have evolved sophisticated mechanisms to control TE activity, the most important being epigenetic silencing. However, the epigenetic control of TEs can also affect genes located nearby that can become epigenetically regulated. It has been proposed that the combination of TE mobilization and the induced changes in the epigenetic landscape could allow a rapid phenotypic adaptation to global environmental changes. In this review, we argue the crucial need to take into account the repeated part of genomes when studying the global impact of epigenetic modifications on an organism. We emphasize more particularly why it is important to carefully consider TEs and what bioinformatic tools can be used to do so. MDPI 2019-03-31 /pmc/articles/PMC6523952/ /pubmed/30935103 http://dx.doi.org/10.3390/genes10040258 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lerat, Emmanuelle Casacuberta, Josep Chaparro, Cristian Vieira, Cristina On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses |
title | On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses |
title_full | On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses |
title_fullStr | On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses |
title_full_unstemmed | On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses |
title_short | On the Importance to Acknowledge Transposable Elements in Epigenomic Analyses |
title_sort | on the importance to acknowledge transposable elements in epigenomic analyses |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523952/ https://www.ncbi.nlm.nih.gov/pubmed/30935103 http://dx.doi.org/10.3390/genes10040258 |
work_keys_str_mv | AT leratemmanuelle ontheimportancetoacknowledgetransposableelementsinepigenomicanalyses AT casacubertajosep ontheimportancetoacknowledgetransposableelementsinepigenomicanalyses AT chaparrocristian ontheimportancetoacknowledgetransposableelementsinepigenomicanalyses AT vieiracristina ontheimportancetoacknowledgetransposableelementsinepigenomicanalyses |