Interpretation of Non-Clinical Data for Prediction of Human Pharmacokinetic Parameters: In Vitro-In Vivo Extrapolation and Allometric Scaling

Extrapolation of pharmacokinetic (PK) parameters from in vitro or in vivo animal to human is one of the main tasks in the drug development process. Translational approaches provide evidence for go or no-go decision-making during drug discovery and the development process, and the prediction of human...

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Detalles Bibliográficos
Autores principales: Choi, Go-Wun, Lee, Yong-Bok, Cho, Hea-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523982/
https://www.ncbi.nlm.nih.gov/pubmed/30959827
http://dx.doi.org/10.3390/pharmaceutics11040168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6523982/
https://www.ncbi.nlm.nih.gov/pubmed/30959827
http://dx.doi.org/10.3390/pharmaceutics11040168

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