Cargando…

Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers

The release profiles of methotrexate, an anticancer drug, from the monoolein liquid crystalline cubic phases were studied. The cubic phases were used either in the form of a lipidic film deposited onto a glassy carbon electrode surface or in the dispersed form of magnetocubosomes, which are consider...

Descripción completa

Detalles Bibliográficos
Autores principales: Mierzwa, Monika, Cytryniak, Adrianna, Krysiński, Paweł, Bilewicz, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524136/
https://www.ncbi.nlm.nih.gov/pubmed/31010165
http://dx.doi.org/10.3390/nano9040636
_version_ 1783419495692369920
author Mierzwa, Monika
Cytryniak, Adrianna
Krysiński, Paweł
Bilewicz, Renata
author_facet Mierzwa, Monika
Cytryniak, Adrianna
Krysiński, Paweł
Bilewicz, Renata
author_sort Mierzwa, Monika
collection PubMed
description The release profiles of methotrexate, an anticancer drug, from the monoolein liquid crystalline cubic phases were studied. The cubic phases were used either in the form of a lipidic film deposited onto a glassy carbon electrode surface or in the dispersed form of magnetocubosomes, which are considered a prospective hybrid drug delivery system. Commonly, cubosomes or liposomes are employed, but not in the case of toxic methotrexate, known to block the receptors responsible for folate transport into the cells. The release profiles of the drug from the lipidic films were monitored electrochemically and described using the Higuchi model. They were also modified via changes in temperature; the release was faster, although it deviated from the model when the temperature was increased. Cubic phase nanoparticles (magnetocubosomes) containing hydrophobic magnetic nanoparticles placed in an alternating magnetic field of low frequency and amplitude, stimulated drug release from the suspension, which was monitored spectroscopically. These new biocompatible hybrid nanomaterials in the dispersed form allow to control the release of the drug at the appropriate sites, can be easily separated or relocated under external magnetic field and await further investigations of their in vitro cytotoxicity and in vivo biodistribution.
format Online
Article
Text
id pubmed-6524136
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-65241362019-06-03 Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers Mierzwa, Monika Cytryniak, Adrianna Krysiński, Paweł Bilewicz, Renata Nanomaterials (Basel) Article The release profiles of methotrexate, an anticancer drug, from the monoolein liquid crystalline cubic phases were studied. The cubic phases were used either in the form of a lipidic film deposited onto a glassy carbon electrode surface or in the dispersed form of magnetocubosomes, which are considered a prospective hybrid drug delivery system. Commonly, cubosomes or liposomes are employed, but not in the case of toxic methotrexate, known to block the receptors responsible for folate transport into the cells. The release profiles of the drug from the lipidic films were monitored electrochemically and described using the Higuchi model. They were also modified via changes in temperature; the release was faster, although it deviated from the model when the temperature was increased. Cubic phase nanoparticles (magnetocubosomes) containing hydrophobic magnetic nanoparticles placed in an alternating magnetic field of low frequency and amplitude, stimulated drug release from the suspension, which was monitored spectroscopically. These new biocompatible hybrid nanomaterials in the dispersed form allow to control the release of the drug at the appropriate sites, can be easily separated or relocated under external magnetic field and await further investigations of their in vitro cytotoxicity and in vivo biodistribution. MDPI 2019-04-19 /pmc/articles/PMC6524136/ /pubmed/31010165 http://dx.doi.org/10.3390/nano9040636 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mierzwa, Monika
Cytryniak, Adrianna
Krysiński, Paweł
Bilewicz, Renata
Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers
title Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers
title_full Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers
title_fullStr Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers
title_full_unstemmed Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers
title_short Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers
title_sort lipidic liquid crystalline cubic phases and magnetocubosomes as methotrexate carriers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524136/
https://www.ncbi.nlm.nih.gov/pubmed/31010165
http://dx.doi.org/10.3390/nano9040636
work_keys_str_mv AT mierzwamonika lipidicliquidcrystallinecubicphasesandmagnetocubosomesasmethotrexatecarriers
AT cytryniakadrianna lipidicliquidcrystallinecubicphasesandmagnetocubosomesasmethotrexatecarriers
AT krysinskipaweł lipidicliquidcrystallinecubicphasesandmagnetocubosomesasmethotrexatecarriers
AT bilewiczrenata lipidicliquidcrystallinecubicphasesandmagnetocubosomesasmethotrexatecarriers