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Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers
The release profiles of methotrexate, an anticancer drug, from the monoolein liquid crystalline cubic phases were studied. The cubic phases were used either in the form of a lipidic film deposited onto a glassy carbon electrode surface or in the dispersed form of magnetocubosomes, which are consider...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524136/ https://www.ncbi.nlm.nih.gov/pubmed/31010165 http://dx.doi.org/10.3390/nano9040636 |
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author | Mierzwa, Monika Cytryniak, Adrianna Krysiński, Paweł Bilewicz, Renata |
author_facet | Mierzwa, Monika Cytryniak, Adrianna Krysiński, Paweł Bilewicz, Renata |
author_sort | Mierzwa, Monika |
collection | PubMed |
description | The release profiles of methotrexate, an anticancer drug, from the monoolein liquid crystalline cubic phases were studied. The cubic phases were used either in the form of a lipidic film deposited onto a glassy carbon electrode surface or in the dispersed form of magnetocubosomes, which are considered a prospective hybrid drug delivery system. Commonly, cubosomes or liposomes are employed, but not in the case of toxic methotrexate, known to block the receptors responsible for folate transport into the cells. The release profiles of the drug from the lipidic films were monitored electrochemically and described using the Higuchi model. They were also modified via changes in temperature; the release was faster, although it deviated from the model when the temperature was increased. Cubic phase nanoparticles (magnetocubosomes) containing hydrophobic magnetic nanoparticles placed in an alternating magnetic field of low frequency and amplitude, stimulated drug release from the suspension, which was monitored spectroscopically. These new biocompatible hybrid nanomaterials in the dispersed form allow to control the release of the drug at the appropriate sites, can be easily separated or relocated under external magnetic field and await further investigations of their in vitro cytotoxicity and in vivo biodistribution. |
format | Online Article Text |
id | pubmed-6524136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65241362019-06-03 Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers Mierzwa, Monika Cytryniak, Adrianna Krysiński, Paweł Bilewicz, Renata Nanomaterials (Basel) Article The release profiles of methotrexate, an anticancer drug, from the monoolein liquid crystalline cubic phases were studied. The cubic phases were used either in the form of a lipidic film deposited onto a glassy carbon electrode surface or in the dispersed form of magnetocubosomes, which are considered a prospective hybrid drug delivery system. Commonly, cubosomes or liposomes are employed, but not in the case of toxic methotrexate, known to block the receptors responsible for folate transport into the cells. The release profiles of the drug from the lipidic films were monitored electrochemically and described using the Higuchi model. They were also modified via changes in temperature; the release was faster, although it deviated from the model when the temperature was increased. Cubic phase nanoparticles (magnetocubosomes) containing hydrophobic magnetic nanoparticles placed in an alternating magnetic field of low frequency and amplitude, stimulated drug release from the suspension, which was monitored spectroscopically. These new biocompatible hybrid nanomaterials in the dispersed form allow to control the release of the drug at the appropriate sites, can be easily separated or relocated under external magnetic field and await further investigations of their in vitro cytotoxicity and in vivo biodistribution. MDPI 2019-04-19 /pmc/articles/PMC6524136/ /pubmed/31010165 http://dx.doi.org/10.3390/nano9040636 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Mierzwa, Monika Cytryniak, Adrianna Krysiński, Paweł Bilewicz, Renata Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers |
title | Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers |
title_full | Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers |
title_fullStr | Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers |
title_full_unstemmed | Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers |
title_short | Lipidic Liquid Crystalline Cubic Phases and Magnetocubosomes as Methotrexate Carriers |
title_sort | lipidic liquid crystalline cubic phases and magnetocubosomes as methotrexate carriers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524136/ https://www.ncbi.nlm.nih.gov/pubmed/31010165 http://dx.doi.org/10.3390/nano9040636 |
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