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The PAF1c Subunit CDC73 Is Required for Mouse Hematopoietic Stem Cell Maintenance but Displays Leukemia-Specific Gene Regulation

The Polymerase Associated Factor 1 complex (PAF1c) functions at the interface of epigenetics and gene transcription. The PAF1c is required for MLL fusion-driven acute myeloid leukemia (AML) through direct regulation of pro-leukemic target genes such as Hoxa9 and Meis1. However, the role of the PAF1c...

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Detalles Bibliográficos
Autores principales:	Saha, Nirmalya, Ropa, James, Chen, Lili, Hu, Hsiangyu, Mysliwski, Maria, Friedman, Ann, Maillard, Ivan, Muntean, Andrew G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524170/ https://www.ncbi.nlm.nih.gov/pubmed/31031188 http://dx.doi.org/10.1016/j.stemcr.2019.03.010

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