Molecular pattern of lncRNAs in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most notable lethal malignancies worldwide. However, the molecular mechanisms involved in the initiation and progression of this disease remain poorly understood. Over the past decade, many studies have demonstrated the important regulatory roles of long...

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Detalles Bibliográficos
Autores principales: Mai, Haoming, Zhou, Bin, Liu, Li, Yang, Fu, Conran, Carly, Ji, Yuan, Hou, Jinlin, Jiang, Deke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6524221/
https://www.ncbi.nlm.nih.gov/pubmed/31097003
http://dx.doi.org/10.1186/s13046-019-1213-0
Descripción
Sumario:Hepatocellular carcinoma (HCC) is one of the most notable lethal malignancies worldwide. However, the molecular mechanisms involved in the initiation and progression of this disease remain poorly understood. Over the past decade, many studies have demonstrated the important regulatory roles of long non-coding RNAs (lncRNAs) in HCC. Here, we comprehensively review recent discoveries regarding HCC-associated lncRNA functions, which we have classified and described according to their mechanism models. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13046-019-1213-0) contains supplementary material, which is available to authorized users.

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